Literature DB >> 3924699

Amplification and enhanced expression of cellular oncogene c-Ki-ras-2 in a human epidermoid carcinoma of the lung.

M Miyaki, C Sato, T Matsui, M Koike, T Mori, G Kosaki, S Takai, A Tonomura, N Tsuchida.   

Abstract

The level of c-Ki-ras-2-specific mRNA was found to be markedly enhanced (10- to 20-fold) in a human epidermoid lung carcinoma transplanted into nude mice, compared with that in other lung carcinomas. Analysis of DNA revealed that c-Ki-ras-2 gene was amplified approximately 10-fold in this carcinoma, while c-Ha-ras, c-myc and c-sis were not amplified. Chromosome abnormalities were also observed in this carcinoma.

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Year:  1985        PMID： 3924699

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  3 in total

Review 1.  Human cancer and cellular oncogenes.

Authors:  S Nishimura; T Sekiya
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

2.  Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression.

Authors:  I A McKay; C J Marshall; C Calés; A Hall
Journal:  EMBO J       Date:  1986-10       Impact factor: 11.598

3.  Differential expression of carcinoembryonic antigen and nonspecific crossreacting antigen genes in human colon adenocarcinomas and normal colon mucosa.

Authors:  C Sato; M Miyaki; S Oikawa; H Nakazato; G Kosaki
Journal:  Jpn J Cancer Res       Date:  1988-04
  3 in total

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