| Literature DB >> 31326616 |
Orietta Pansarasa1, Cristiana Pistono2, Annalisa Davin2, Matteo Bordoni3, Maria Chiara Mimmi4, Antonio Guaita2, Cristina Cereda3.
Abstract
Frailty is a complex geriatric syndrome associated with biological vulnerability to stressors and decreased physiological reserve. Its etiology and pathogenesis are not completely understood, although various causes and complex pathways have been proposed. Immune system alterations (immunosenescence and "InflammAging") have been suggested to contribute to frailty, but a precise causative role of such alterations remains to be determined. Genetic studies support the suggestion of immune system involvement in frailty: genetic variants in genes involved in immune system function have been associated with the syndrome. Interestingly, nutritional status, through its effects on cellular metabolism, may also influence the immune system, i.e. hormone and cytokine (mainly adipocytokine) levels, and immune cell populations and function, increasing inflammation and contributing to frailty. This review aims to discuss the role of immune system alterations in frailty, analyzing the role of genetic factors in frailty onset and the impact of diet on inflammation and, in turn, on frailty.Entities:
Keywords: Frailty syndrome; Immune system; Inflamm aging; Nutrients; SNP
Mesh：
Year: 2019 PMID： 31326616 DOI： 10.1016/j.arr.2019.100935
Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895