Literature DB >> 32770212

The "Virtual Digital Twins" Concept in Precision Nutrition.

Kalliopi Gkouskou1,2, Ioannis Vlastos1, Petros Karkalousos3, Dimitrios Chaniotis3, Despina Sanoudou4,5,6, Aristides G Eliopoulos1,5,6.   

Abstract

Nutritional and lifestyle changes remain at the core of healthy aging and disease prevention. Accumulating evidence underscores the impact of genetic, metabolic, and host gut microbial factors on individual responses to nutrients, paving the way for the stratification of nutritional guidelines. However, technological advances that incorporate biological, nutritional, lifestyle, and health data at an unprecedented scale and depth conceptualize a future where preventative dietary interventions will exceed stratification and will be highly individualized. We herein discuss how genetic information combined with longitudinal metabolomic, immune, behavioral, and gut microbial parameters, and bioclinical variables could define a digital replica of oneself, a "virtual digital twin," which could serve to guide nutrition in a personalized manner. Such a model may revolutionize the management of obesity and its comorbidities, and provide a pillar for healthy aging.
Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.

Entities:  

Keywords:  digital medicine; digital twin; epigenome; immunome; microbiome; nutrigenetics; nutrition; obesity

Mesh：

Year:  2020        PMID： 32770212      PMCID： PMC7666894          DOI： 10.1093/advances/nmaa089

Source DB:  PubMed          Journal:  Adv Nutr        ISSN： 2161-8313            Impact factor:   8.701


  100 in total

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Authors:  Yiorgos Apidianakis; Aristides G Eliopoulos
Journal:  EMBO Rep       Date:  2015-09-09       Impact factor: 8.807

2.  An inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance.

Authors:  Mònica Recasens; Abel López-Bermejo; Wifredo Ricart; Joan Vendrell; Roser Casamitjana; José Manuel Fernández-Real
Journal:  J Clin Endocrinol Metab       Date:  2004-10-14       Impact factor: 5.958

3.  Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa.

Authors:  Carlotta De Filippo; Duccio Cavalieri; Monica Di Paola; Matteo Ramazzotti; Jean Baptiste Poullet; Sebastien Massart; Silvia Collini; Giuseppe Pieraccini; Paolo Lionetti
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-02       Impact factor: 11.205

4.  HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss: The POUNDS Lost trial and DIRECT.

Authors:  Tao Huang; Tiange Wang; Yoriko Heianza; Dianjianyi Sun; Kerry Ivey; Ronen Durst; Dan Schwarzfuchs; Meir J Stampfer; George A Bray; Frank M Sacks; Iris Shai; Lu Qi
Journal:  Diabetes Obes Metab       Date:  2018-03-05       Impact factor: 6.577

5.  Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline.

Authors:  Wei Sha; Kerry-Ann da Costa; Leslie M Fischer; Michael V Milburn; Kay A Lawton; Alvin Berger; Wei Jia; Steven H Zeisel
Journal:  FASEB J       Date:  2010-04-06       Impact factor: 5.191

6.  An obesity-associated gut microbiome with increased capacity for energy harvest.

Authors:  Peter J Turnbaugh; Ruth E Ley; Michael A Mahowald; Vincent Magrini; Elaine R Mardis; Jeffrey I Gordon
Journal:  Nature       Date:  2006-12-21       Impact factor: 49.962

Review 7.  Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans.

Authors:  T Pecht; A Gutman-Tirosh; N Bashan; A Rudich
Journal:  Obes Rev       Date:  2013-11-20       Impact factor: 9.213

8.  The body-mass index of twins who have been reared apart.

Authors:  A J Stunkard; J R Harris; N L Pedersen; G E McClearn
Journal:  N Engl J Med       Date:  1990-05-24       Impact factor: 91.245

Review 9.  Finding the missing heritability of complex diseases.

Authors:  Teri A Manolio; Francis S Collins; Nancy J Cox; David B Goldstein; Lucia A Hindorff; David J Hunter; Mark I McCarthy; Erin M Ramos; Lon R Cardon; Aravinda Chakravarti; Judy H Cho; Alan E Guttmacher; Augustine Kong; Leonid Kruglyak; Elaine Mardis; Charles N Rotimi; Montgomery Slatkin; David Valle; Alice S Whittemore; Michael Boehnke; Andrew G Clark; Evan E Eichler; Greg Gibson; Jonathan L Haines; Trudy F C Mackay; Steven A McCarroll; Peter M Visscher
Journal:  Nature       Date:  2009-10-08       Impact factor: 49.962

Review 10.  Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications.

Authors:  Hassan S Dashti; Frank Ajl Scheer; Paul F Jacques; Stefania Lamon-Fava; José M Ordovás
Journal:  Adv Nutr       Date:  2015-11-13       Impact factor: 8.701
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  14 in total

Review 1.  A Scoping Review of Digital Twins in the Context of the Covid-19 Pandemic.

Authors:  Asiya Khan; Madison Milne-Ives; Edward Meinert; Gloria E Iyawa; Ray B Jones; Alex N Josephraj
Journal:  Biomed Eng Comput Biol       Date:  2022-05-24

2.  In silico trials predict that combination strategies for enhancing vesicular stomatitis oncolytic virus are determined by tumor aggressivity.

Authors:  Adrianne L Jenner; Tyler Cassidy; Katia Belaid; Marie-Claude Bourgeois-Daigneault; Morgan Craig
Journal:  J Immunother Cancer       Date:  2021-02       Impact factor: 13.751

Review 3.  Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials.

Authors:  Maria G Grammatikopoulou; Konstantinos Gkiouras; Stefanos Τ Papageorgiou; Ioannis Myrogiannis; Ioannis Mykoniatis; Theodora Papamitsou; Dimitrios P Bogdanos; Dimitrios G Goulis
Journal:  Nutrients       Date:  2020-09-29       Impact factor: 5.717

Review 4.  A New Paradigm for Clinical Nutrition Services in the Era of the Fourth Industrial Revolution.

Authors:  Ga Young Kim; Jung-Sook Seo
Journal:  Clin Nutr Res       Date:  2021-04-19

Review 5.  Genetically Guided Mediterranean Diet for the Personalized Nutritional Management of Type 2 Diabetes Mellitus.

Authors:  Kalliopi Gkouskou; Evgenia Lazou; Efstathios Skoufas; Aristides G Eliopoulos
Journal:  Nutrients       Date:  2021-01-25       Impact factor: 5.717

6.  Genetically-Guided Medical Nutrition Therapy in Type 2 Diabetes Mellitus and Pre-diabetes: A Series of n-of-1 Superiority Trials.

Authors:  Kalliopi K Gkouskou; Maria G Grammatikopoulou; Evgenia Lazou; Despina Sanoudou; Dimitrios G Goulis; Aristides G Eliopoulos
Journal:  Front Nutr       Date:  2022-02-21

7.  Darling: A Web Application for Detecting Disease-Related Biomedical Entity Associations with Literature Mining.

Authors:  Evangelos Karatzas; Fotis A Baltoumas; Ioannis Kasionis; Despina Sanoudou; Aristides G Eliopoulos; Theodosios Theodosiou; Ioannis Iliopoulos; Georgios A Pavlopoulos
Journal:  Biomolecules       Date:  2022-03-30

Review 8.  The Challenge and Importance of Integrating Drug-Nutrient-Genome Interactions in Personalized Cardiovascular Healthcare.

Authors:  Ioannis Stouras; Theodore G Papaioannou; Konstantinos Tsioufis; Aristides G Eliopoulos; Despina Sanoudou
Journal:  J Pers Med       Date:  2022-03-22

9.  Perspective: A Framework for Addressing Dynamic Food Consumption Processes.

Authors:  Jennifer C Taylor; Margaret Allman-Farinelli; Juliana Chen; Julia M Gauglitz; Dina Hamideh; Marta M Jankowska; Abigail J Johnson; Anna Rangan; Donna Spruijt-Metz; Jiue-An Yang; Eric Hekler
Journal:  Adv Nutr       Date:  2022-08-01       Impact factor: 11.567

10.  Retrospective study of glycemic variability, BMI, and blood pressure in diabetes patients in the Digital Twin Precision Treatment Program.

Authors:  Paramesh Shamanna; Mala Dharmalingam; Rakesh Sahay; Jahangir Mohammed; Maluk Mohamed; Terrence Poon; Nathan Kleinman; Mohamed Thajudeen
Journal:  Sci Rep       Date:  2021-07-21       Impact factor: 4.379
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