Literature DB >> 34072224

Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System.

Genieve Ee Chia Yeo1, Min Hwei Ng1, Fazlina Binti Nordin1, Jia Xian Law1.   

Abstract

Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naïve cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence.

Entities:  

Keywords:  aging; frailty; immune system; inflammaging; mesenchymal stem cells

Year:  2021        PMID： 34072224     DOI： 10.3390/ijms22115749

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  180 in total

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Authors:  Estelle Bettelli; Yijun Carrier; Wenda Gao; Thomas Korn; Terry B Strom; Mohamed Oukka; Howard L Weiner; Vijay K Kuchroo
Journal:  Nature       Date:  2006-04-30       Impact factor: 49.962

2.  Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.

Authors:  Wen Xue; Lars Zender; Cornelius Miething; Ross A Dickins; Eva Hernando; Valery Krizhanovsky; Carlos Cordon-Cardo; Scott W Lowe
Journal:  Nature       Date:  2007-01-24       Impact factor: 49.962

3.  STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells.

Authors:  Yue Li; Weiren Liu; Xiaqun Guan; Jamie Truscott; John W Creemers; Hung-Lin Chen; Marko Pesu; Rami G El Abiad; Bahri Karacay; Joseph F Urban; David E Elliott; Mark H Kaplan; Bruce R Blazar; M Nedim Ince
Journal:  J Immunol       Date:  2018-09-28       Impact factor: 5.422

4.  Age associated oxidative damage in lymphocytes.

Authors:  Nandeslu Gautam; Subhasis Das; Santanu Kar Mahapatra; Subhankari Prasad Chakraborty; Pratip Kumar Kundu; Somenath Roy
Journal:  Oxid Med Cell Longev       Date:  2010 Jul-Aug       Impact factor: 6.543

Review 5.  Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation: Time To T Up the Thymus.

Authors:  Mohammed S Chaudhry; Enrico Velardi; Florent Malard; Marcel R M van den Brink
Journal:  J Immunol       Date:  2017-01-01       Impact factor: 5.422

6.  Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition.

Authors:  Sellamuthu Subbanna Gounder; Basri Johan Jeet Abdullah; Nur Ezzati Izyan Binti Mohd Radzuanb; Farah Dalila Binti Mohd Zain; Nurhidayah Bt Mohamad Sait; Corine Chua; Baskar Subramani
Journal:  Anal Cell Pathol (Amst)       Date:  2018-08-02       Impact factor: 2.916

7.  Targeted Next Generation Sequencing Revealed a Novel Homozygous Loss-of-Function Mutation in ILDR1 Gene Causes Autosomal Recessive Nonsyndromic Sensorineural Hearing Loss in a Chinese Family.

Authors:  Jinxia An; Jie Yang; Yan Wang; Yanxia Wang; Baicheng Xu; Guangmei Xie; Sanming Chai; Xiaoling Liu; Sijuan Xu; Xiaoxiao Wen; Qing He; Huijun Liu; Chen Li; Subrata Kumar Dey; Yali Ni; Santasree Banerjee
Journal:  Front Genet       Date:  2019-02-05       Impact factor: 4.599

Review 8.  Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19.

Authors:  Loubna Mazini; Mohamed Ezzoubi; Gabriel Malka
Journal:  Stem Cell Res Ther       Date:  2021-01-04       Impact factor: 6.832

9.  A human circulating immune cell landscape in aging and COVID-19.

Authors:  Yingfeng Zheng; Xiuxing Liu; Wenqing Le; Lihui Xie; He Li; Wen Wen; Si Wang; Hongyang Wang; Guang-Hui Liu; Shuai Ma; Zhaohao Huang; Jinguo Ye; Wen Shi; Yanxia Ye; Zunpeng Liu; Moshi Song; Weiqi Zhang; Jing-Dong J Han; Juan Carlos Izpisua Belmonte; Chuanle Xiao; Jing Qu; Wenru Su
Journal:  Protein Cell       Date:  2020-08-11       Impact factor: 14.870

10.  Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence.

Authors:  Elizabeth Sapey; Hannah Greenwood; Georgia Walton; Elizabeth Mann; Alexander Love; Natasha Aaronson; Robert H Insall; Robert A Stockley; Janet M Lord
Journal:  Blood       Date:  2013-11-04       Impact factor: 22.113
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  1 in total

1.  Untargeted Metabolomics Reveal the Protective Effect of Bone Marrow Mesenchymal Stem Cell Transplantation Against Ovariectomy-Induced Osteoporosis in Mice.

Authors:  Weizhou Wang; Yanghao Wang; Jun Hu; Hao Duan; Zhihua Wang; Liang Yin; Fei He
Journal:  Cell Transplant       Date:  2022 Jan-Dec       Impact factor: 4.064
  1 in total

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