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Literature DB >> 3132612

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

Abstract

We have isolated a cDNA copy of a truncated C gamma 2b transcript produced by Abelson murine leukemia virus transformants that spontaneously switch from mu to gamma 2b. The initiation site of this transcript was 2 kilobases 5' to the gamma 2b switch recombination region, demonstrating its germ line origin. Nucleotide sequence analyses suggest that this transcript does not encode a protein. Expression of germ line gamma 2b transcripts in Abelson murine leukemia virus transformants and in normal spleen cells correlated with endogenous gamma 2b class switch activity.

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Year: 1988 PMID： 3132612 PMCID： PMC363353 DOI： 10.1128/mcb.8.4.1849-1852.1988

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

14 in total

1. Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.

Authors: P W Tucker; K B Marcu; N Newell; J Richards; F R Blattner
Journal: Science Date: 1979-12-14 Impact factor: 47.728

Review 2. Control of immunoglobulin class switch recombination.

Authors: A Radbruch; C Burger; S Klein; W Müller
Journal: Immunol Rev Date: 1986-02 Impact factor: 12.988

3. C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon.

Authors: G G Lennon; R P Perry
Journal: Nature Date: 1985 Dec 5-11 Impact factor: 49.962

4. In vivo sequence requirements of the SV40 early promotor region.

Authors: C Benoist; P Chambon
Journal: Nature Date: 1981-03-26 Impact factor: 49.962

5. B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo.

Authors: A Ephrussi; G M Church; S Tonegawa; W Gilbert
Journal: Science Date: 1985-01-11 Impact factor: 47.728

6. Immunoglobulin heavy-chain constant-region genes.

Authors: K B Marcu
Journal: Cell Date: 1982-07 Impact factor: 41.582

7. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

Authors: F W Alt; N Rosenberg; V Enea; E Siden; D Baltimore
Journal: Mol Cell Biol Date: 1982-04 Impact factor: 4.272

8. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain.

Authors: A Shimizu; N Takahashi; Y Yaoita; T Honjo
Journal: Cell Date: 1982-03 Impact factor: 41.582

9. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

Authors: J Stavnezer-Nordgren; S Sirlin
Journal: EMBO J Date: 1986-01 Impact factor: 11.598

10. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

Authors: G D Yancopoulos; R A DePinho; K A Zimmerman; S G Lutzker; N Rosenberg; F W Alt
Journal: EMBO J Date: 1986-12-01 Impact factor: 11.598

48 in total

1. Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

Authors: H Leung; N Maizels
Journal: Proc Natl Acad Sci U S A Date: 1992-05-01 Impact factor: 11.205

2. Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells.

Authors: D J Martin; B G van Ness
Journal: Mol Cell Biol Date: 1990-05 Impact factor: 4.272

3. The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription.

Authors: L K Su; T Kadesch
Journal: Mol Cell Biol Date: 1990-06 Impact factor: 4.272

4. Sequences of human immunoglobulin switch regions: implications for recombination and transcription.

Authors: F C Mills; J S Brooker; R D Camerini-Otero
Journal: Nucleic Acids Res Date: 1990-12-25 Impact factor: 16.971

5. Structure and expression of mouse germline immunoglobulin gamma 3 heavy chain transcripts induced by the mitogen lipopolysaccharide.

Authors: S Gerondakis; C Gaff; D J Goodman; R J Grumont
Journal: Immunogenetics Date: 1991 Impact factor: 2.846

6. mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end.

Authors: G A Neale; G R Kitchingman
Journal: Nucleic Acids Res Date: 1991-05-11 Impact factor: 16.971

7. Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site.

Authors: Deepankar Roy; Zheng Zhang; Zhengfei Lu; Chih-Lin Hsieh; Michael R Lieber
Journal: Mol Cell Biol Date: 2010-01 Impact factor: 4.272