Literature DB >> 31324714

Driving tau into phase-separated liquid droplets.

Martin Margittai1.   

Abstract

Liquid-liquid phase separation of tau protein has been implicated in normal biological function as well as neurodegenerative diseases, including Alzheimer's. However, knowledge about these links is still scant, and the mechanisms driving tau into liquid droplets are poorly understood. A simplified in vitro system that uses unmodified human tau protein now suggests electrostatic interactions provide the basic instructions underlying liquid droplet formation.
© 2019 Margittai.

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Year:  2019        PMID： 31324714      PMCID： PMC6643035          DOI： 10.1074/jbc.H119.009703

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  Identification of the Tau phosphorylation pattern that drives its aggregation.

Authors:  Clément Despres; Cillian Byrne; Haoling Qi; François-Xavier Cantrelle; Isabelle Huvent; Béatrice Chambraud; Etienne-Emile Baulieu; Yves Jacquot; Isabelle Landrieu; Guy Lippens; Caroline Smet-Nocca
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-07       Impact factor: 11.205

2.  Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions.

Authors:  Yanxian Lin; James McCarty; Jennifer N Rauch; Kris T Delaney; Kenneth S Kosik; Glenn H Fredrickson; Joan-Emma Shea; Songi Han
Journal:  Elife       Date:  2019-04-05       Impact factor: 8.140

Review 3.  Matter over mind: Liquid phase separation and neurodegeneration.

Authors:  Shana Elbaum-Garfinkle
Journal:  J Biol Chem       Date:  2019-03-26       Impact factor: 5.157

Review 4.  Protein Phase Separation: A New Phase in Cell Biology.

Authors:  Steven Boeynaems; Simon Alberti; Nicolas L Fawzi; Tanja Mittag; Magdalini Polymenidou; Frederic Rousseau; Joost Schymkowitz; James Shorter; Benjamin Wolozin; Ludo Van Den Bosch; Peter Tompa; Monika Fuxreiter
Journal:  Trends Cell Biol       Date:  2018-03-27       Impact factor: 20.808

5.  RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth.

Authors:  Paul D Dinkel; Michael R Holden; Nadira Matin; Martin Margittai
Journal:  Biochemistry       Date:  2015-07-27       Impact factor: 3.162

6.  Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.

Authors:  Amayra Hernández-Vega; Marcus Braun; Lara Scharrel; Marcus Jahnel; Susanne Wegmann; Bradley T Hyman; Simon Alberti; Stefan Diez; Anthony A Hyman
Journal:  Cell Rep       Date:  2017-09-05       Impact factor: 9.423

7.  RNA stores tau reversibly in complex coacervates.

Authors:  Xuemei Zhang; Yanxian Lin; Neil A Eschmann; Hongjun Zhou; Jennifer N Rauch; Israel Hernandez; Elmer Guzman; Kenneth S Kosik; Songi Han
Journal:  PLoS Biol       Date:  2017-07-06       Impact factor: 8.029

8.  Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions.

Authors:  Solomiia Boyko; Xu Qi; Tien-Hao Chen; Krystyna Surewicz; Witold K Surewicz
Journal:  J Biol Chem       Date:  2019-05-16       Impact factor: 5.157

Review 9.  Biomolecular condensates: organizers of cellular biochemistry.

Authors:  Salman F Banani; Hyun O Lee; Anthony A Hyman; Michael K Rosen
Journal:  Nat Rev Mol Cell Biol       Date:  2017-02-22       Impact factor: 94.444

10.  Tau protein liquid-liquid phase separation can initiate tau aggregation.

Authors:  Susanne Wegmann; Bahareh Eftekharzadeh; Katharina Tepper; Katarzyna M Zoltowska; Rachel E Bennett; Simon Dujardin; Pawel R Laskowski; Danny MacKenzie; Tarun Kamath; Caitlin Commins; Charles Vanderburg; Allyson D Roe; Zhanyun Fan; Amandine M Molliex; Amayra Hernandez-Vega; Daniel Muller; Anthony A Hyman; Eckhard Mandelkow; J Paul Taylor; Bradley T Hyman
Journal:  EMBO J       Date:  2018-02-22       Impact factor: 11.598
  10 in total

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