| Literature DB >> 31308545 |
Hunna J Watson1,2,3, Zeynep Yilmaz1,4, Laura M Thornton1, Christopher Hübel5,6, Jonathan R I Coleman5,7, Héléna A Gaspar5,7, Julien Bryois6, Anke Hinney8, Virpi M Leppä6, Manuel Mattheisen9,10,11,12, Sarah E Medland13, Stephan Ripke14,15,16, Shuyang Yao6, Paola Giusti-Rodríguez4, Ken B Hanscombe17, Kirstin L Purves5, Roger A H Adan18,19,20, Lars Alfredsson21, Tetsuya Ando22, Ole A Andreassen23, Jessica H Baker1, Wade H Berrettini24, Ilka Boehm25, Claudette Boni26, Vesna Boraska Perica27,28, Katharina Buehren29, Roland Burghardt30, Matteo Cassina31, Sven Cichon32, Maurizio Clementi31, Roger D Cone33, Philippe Courtet34, Scott Crow35, James J Crowley4,10, Unna N Danner19, Oliver S P Davis36,37, Martina de Zwaan38, George Dedoussis39, Daniela Degortes40, Janiece E DeSocio41, Danielle M Dick42, Dimitris Dikeos43, Christian Dina44, Monika Dmitrzak-Weglarz45, Elisa Docampo46,47,48, Laramie E Duncan49, Karin Egberts50, Stefan Ehrlich25, Geòrgia Escaramís46,47,48, Tõnu Esko51,52, Xavier Estivill46,47,48,53, Anne Farmer5, Angela Favaro40, Fernando Fernández-Aranda54,55, Manfred M Fichter56,57, Krista Fischer51, Manuel Föcker8, Lenka Foretova58, Andreas J Forstner32,59,60,61,62, Monica Forzan31, Christopher S Franklin27, Steven Gallinger63, Ina Giegling64, Johanna Giuranna8, Fragiskos Gonidakis65, Philip Gorwood26,66, Monica Gratacos Mayora46,47,48, Sébastien Guillaume34, Yiran Guo67, Hakon Hakonarson67,68, Konstantinos Hatzikotoulas27,69, Joanna Hauser70, Johannes Hebebrand8, Sietske G Helder5,71, Stefan Herms32,60,62, Beate Herpertz-Dahlmann29, Wolfgang Herzog72, Laura M Huckins27,73, James I Hudson74, Hartmut Imgart75, Hidetoshi Inoko76, Vladimir Janout77, Susana Jiménez-Murcia54,55, Antonio Julià78, Gursharan Kalsi5, Deborah Kaminská79, Jaakko Kaprio80,81, Leila Karhunen82, Andreas Karwautz83, Martien J H Kas18,84, James L Kennedy85,86,87, Anna Keski-Rahkonen80, Kirsty Kiezebrink88, Youl-Ri Kim89, Lars Klareskog90, Kelly L Klump91, Gun Peggy S Knudsen92, Maria C La Via1, Stephanie Le Hellard93,94,95, Robert D Levitan85,86,87, Dong Li67, Lisa Lilenfeld96, Bochao Danae Lin18, Jolanta Lissowska97, Jurjen Luykx18, Pierre J Magistretti98,99, Mario Maj100, Katrin Mannik51,101, Sara Marsal78, Christian R Marshall102, Morten Mattingsdal23, Sara McDevitt103,104, Peter McGuffin5, Andres Metspalu51,105, Ingrid Meulenbelt106, Nadia Micali107,108,109, Karen Mitchell110, Alessio Maria Monteleone100, Palmiero Monteleone111, Melissa A Munn-Chernoff1, Benedetta Nacmias112, Marie Navratilova58, Ioanna Ntalla39, Julie K O'Toole113, Roel A Ophoff18,114, Leonid Padyukov90, Aarno Palotie52,81,115, Jacques Pantel26, Hana Papezova79, Dalila Pinto73, Raquel Rabionet116,117,118, Anu Raevuori80, Nicolas Ramoz26, Ted Reichborn-Kjennerud92,119, Valdo Ricca112,120, Samuli Ripatti52,80,121, Franziska Ritschel25,122, Marion Roberts5,123,124, Alessandro Rotondo125, Dan Rujescu56,64, Filip Rybakowski126, Paolo Santonastaso127, André Scherag128, Stephen W Scherer129, Ulrike Schmidt7,130, Nicholas J Schork131, Alexandra Schosser132, Jochen Seitz29, Lenka Slachtova133, P Eline Slagboom106, Margarita C T Slof-Op 't Landt134,135, Agnieszka Slopien136, Sandro Sorbi112,137, Beata Świątkowska138, Jin P Szatkiewicz4, Ioanna Tachmazidou27, Elena Tenconi40, Alfonso Tortorella139,140, Federica Tozzi141, Janet Treasure7,130, Artemis Tsitsika142, Marta Tyszkiewicz-Nwafor136, Konstantinos Tziouvas143, Annemarie A van Elburg19,144, Eric F van Furth134,135, Gudrun Wagner83, Esther Walton25, Elisabeth Widen81, Eleftheria Zeggini27,69, Stephanie Zerwas1, Stephan Zipfel145, Andrew W Bergen146,147, Joseph M Boden148, Harry Brandt149, Steven Crawford149, Katherine A Halmi150, L John Horwood148, Craig Johnson151, Allan S Kaplan85,86,87, Walter H Kaye152, James E Mitchell153, Catherine M Olsen13, John F Pearson154, Nancy L Pedersen6, Michael Strober155,156, Thomas Werge157, David C Whiteman13, D Blake Woodside86,87,158,159, Garret D Stuber1,160, Scott Gordon13, Jakob Grove9,161,162,163, Anjali K Henders164, Anders Juréus6, Katherine M Kirk13, Janne T Larsen161,165,166, Richard Parker13, Liselotte Petersen161,165,166, Jennifer Jordan123,167, Martin Kennedy168, Grant W Montgomery13,164,169, Tracey D Wade170, Andreas Birgegård10,11, Paul Lichtenstein6, Claes Norring10,11, Mikael Landén6,171, Nicholas G Martin13, Preben Bo Mortensen161,165,166, Patrick F Sullivan1,4,6, Gerome Breen5,7, Cynthia M Bulik172,173,174.
Abstract
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.Entities:
Mesh：
Year: 2019 PMID： 31308545 PMCID： PMC6779477 DOI： 10.1038/s41588-019-0439-2
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330