Hunna J Watson1,2,3, Elizabeth W Diemer4, Stephanie Zerwas1, Kristin Gustavson5,6, Gun Peggy Knudsen5, Leila Torgersen5, Ted Reichborn-Kjennerud7,8, Cynthia M Bulik1,9,10. 1. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 2. School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia. 3. School of Psychology and Speech Pathology, Curtin University, Perth, Western Australia, Australia. 4. Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts. 5. Department of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway. 6. Department of Psychology, University of Oslo, Oslo, Norway. 7. Division of Mental Health Services, Akershus University Hospital, Oslo, Norway. 8. Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 9. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 10. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Abstract
OBJECTIVE: The fetal programming model hypothesizes that developmental programming in utero and in early life induces adaptations that predetermine the adult phenotype. This study investigated whether prenatal/perinatal complications are associated with lifetime eating disorders in women. METHOD: Participants included 46,373 adult women enrolled in the Norwegian Mother and Child Cohort Study (den norske Mor & barn-undersøkelsen [MoBa]). MoBa mothers and their mothers (MoBa grandmothers) were the focus of the current study. MoBa mothers with lifetime eating disorders were compared to a referent group. RESULTS: MoBa mothers who weighed more at birth (birth weight, adjusted odds ratio [OR] = 1.14; 95% confidence interval [CI]: 1.10-1.19) or were born large-for-gestational-age (adjusted OR = 1.39; 95% CI: 1.27-1.52) were more likely to develop binge-eating disorder in later life. MoBa mothers who weighed less at birth were more likely to develop anorexia nervosa (birth weight, adjusted OR = 0.88; 95% CI: 0.81-0.95). Bulimia nervosa and purging disorder (PD) were not significantly predicted by the prenatal and perinatal factors examined. DISCUSSION: Results of this study, which include the first known investigation of prenatal and perinatal factors in binge-eating disorder and PD, suggest that fetal programming may be relevant to the development of anorexia nervosa and binge-eating disorder. Future genetically informative research is needed to help disentangle whether these associations are a function of genetic influences or a true environmental fetal programming effect.
OBJECTIVE: The fetal programming model hypothesizes that developmental programming in utero and in early life induces adaptations that predetermine the adult phenotype. This study investigated whether prenatal/perinatal complications are associated with lifetime eating disorders in women. METHOD:Participants included 46,373 adult women enrolled in the Norwegian Mother and Child Cohort Study (den norske Mor & barn-undersøkelsen [MoBa]). MoBa mothers and their mothers (MoBa grandmothers) were the focus of the current study. MoBa mothers with lifetime eating disorders were compared to a referent group. RESULTS:MoBa mothers who weighed more at birth (birth weight, adjusted odds ratio [OR] = 1.14; 95% confidence interval [CI]: 1.10-1.19) or were born large-for-gestational-age (adjusted OR = 1.39; 95% CI: 1.27-1.52) were more likely to develop binge-eating disorder in later life. MoBa mothers who weighed less at birth were more likely to develop anorexia nervosa (birth weight, adjusted OR = 0.88; 95% CI: 0.81-0.95). Bulimia nervosa and purging disorder (PD) were not significantly predicted by the prenatal and perinatal factors examined. DISCUSSION: Results of this study, which include the first known investigation of prenatal and perinatal factors in binge-eating disorder and PD, suggest that fetal programming may be relevant to the development of anorexia nervosa and binge-eating disorder. Future genetically informative research is needed to help disentangle whether these associations are a function of genetic influences or a true environmental fetal programming effect.
Authors: Linda Mustelin; Yasmina Silén; Anu Raevuori; Hans W Hoek; Jaakko Kaprio; Anna Keski-Rahkonen Journal: J Psychiatr Res Date: 2016-03-10 Impact factor: 4.791
Authors: Roy M Nilsen; Stein Emil Vollset; Håkon K Gjessing; Rolv Skjaerven; Kari K Melve; Patricia Schreuder; Elin R Alsaker; Kjell Haug; Anne Kjersti Daltveit; Per Magnus Journal: Paediatr Perinat Epidemiol Date: 2009-11 Impact factor: 3.980
Authors: Mateusz Grajek; Karolina Krupa-Kotara; Martina Grot; Maria Kujawińska; Paulina Helisz; Weronika Gwioździk; Agnieszka Białek-Dratwa; Wiktoria Staśkiewicz; Joanna Kobza Journal: Int J Environ Res Public Health Date: 2022-08-16 Impact factor: 4.614
Authors: María Martínez-Olcina; Jacobo A Rubio-Arias; Cristina Reche-García; Belén Leyva-Vela; María Hernández-García; Juan José Hernández-Morante; Alejandro Martínez-Rodríguez Journal: Medicina (Kaunas) Date: 2020-07-15 Impact factor: 2.430