Literature DB >> 31301048

Sperm DNA Fragmentation: Consequences for Reproduction.

Luke Simon1, Benjamin Emery1, Douglas T Carrell2.   

Abstract

DNA fragmentation, or the accumulation of single- and double-strand DNA breaks, is a common property of sperm, and an increase in the level of sperm DNA fragmentation is known to influence natural reproduction. The effect of sperm DNA fragmentation on male infertility and assisted reproductive treatment (ART) outcomes remains controversial and is one of the most frequently debated topics of reproductive medicine. For the past 30 years, a number of assays have been developed to quantify the level of sperm DNA fragmentation. In this chapter, we review the causes of sperm DNA fragmentation, describe the commonly used tests to evaluate these abnormalities, and perform a systematic review of existing studies to determine the impact of sperm DNA fragmentation on male fertility and ART outcomes.

Entities:  

Keywords:  ART outcomes; Comet assay; Male infertility; SCD assay; SCSA; Sperm DNA fragmentation; TUNEL assay

Mesh：

Year:  2019        PMID： 31301048     DOI： 10.1007/978-3-030-21664-1_6

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  10 in total

1.  Sperm selection during ICSI treatments reduces single- but not double-strand DNA break values compared to the semen sample.

Authors:  Sandra Lara-Cerrillo; Jordi Ribas-Maynou; Candela Rosado-Iglesias; Tania Lacruz-Ruiz; Jordi Benet; Agustín García-Peiró
Journal:  J Assist Reprod Genet       Date:  2021-03-04       Impact factor: 3.412

Review 2.  Male infertility due to testicular disorders.

Authors:  Aditi Sharma; Suks Minhas; Waljit S Dhillo; Channa N Jayasena
Journal:  J Clin Endocrinol Metab       Date:  2021-01-23       Impact factor: 5.958

3.  Microbiological Evaluation and Sperm DNA Fragmentation in Semen Samples of Patients Undergoing Fertility Investigation.

Authors:  Chiara Pagliuca; Federica Cariati; Francesca Bagnulo; Elena Scaglione; Consolata Carotenuto; Fabrizio Farina; Valeria D'Argenio; Francesca Carraturo; Paola D'Aprile; Mariateresa Vitiello; Ida Strina; Carlo Alviggi; Roberta Colicchio; Rossella Tomaiuolo; Paola Salvatore
Journal:  Genes (Basel)       Date:  2021-04-27       Impact factor: 4.096

4.  DNA fragmentation index (DFI) as a measure of sperm quality and fertility in mice.

Authors:  Ming-Wen Li; K C Kent Lloyd
Journal:  Sci Rep       Date:  2020-03-02       Impact factor: 4.379

5.  Decreased DNA Repair Ability: A Mechanism for Low Early Embryonic Development Potential of Oocytes From Overweight Patients After Fertilization in IVF Cycles.

Authors:  Hui Li; Huan Wang; Jing Zhu; Jianmin Xu; Yuqing Jiang; Wenhui Chen; Yingpu Sun; Qingling Yang
Journal:  Front Endocrinol (Lausanne)       Date:  2021-11-23       Impact factor: 5.555

6.  Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm.

Authors:  Lijie Liu; Shanhua Mao; Kuangyang Chen; Jiarong Dai; Shuoshuo Jin; Lijiao Chen; Yahao Wang; Lina Guo; Yiting Yang; Chongwen Zhan; Zuquan Xiong; Hua Diao; Yuchuan Zhou; Qiang Ding; Xuanchun Wang
Journal:  Int J Mol Sci       Date:  2022-09-03       Impact factor: 6.208

7.  Vapour fast freezing with low semen volumes can highly improve motility and viability or DNA quality of cryopreserved human spermatozoa.

Authors:  Valentina Arciero; Oumaima Ammar; Mario Maggi; Linda Vignozzi; Monica Muratori; Sara Dabizzi
Journal:  Andrology       Date:  2022-06-27       Impact factor: 4.456

8.  Detailed cell-level analysis of sperm nuclear quality among the different hypo-osmotic swelling test (HOST) classes.

Authors:  Adrien Bloch; Eli J Rogers; Cynthia Nicolas; Tanguy Martin-Denavit; Miguel Monteiro; Daniel Thomas; Hélène Morel; Rachel Lévy; Jean-Pierre Siffroi; Charlotte Dupont; Alexandre Rouen
Journal:  J Assist Reprod Genet       Date:  2021-06-02       Impact factor: 3.357

9.  Effects of common Gram-negative pathogens causing male genitourinary-tract infections on human sperm functions.

Authors:  Maria Torcia; Elisabetta Baldi; Sara Marchiani; Ilaria Baccani; Lara Tamburrino; Giorgio Mattiuz; Sabrina Nicolò; Chiara Bonaiuto; Carmen Panico; Linda Vignozzi; Alberto Antonelli; Gian Maria Rossolini
Journal:  Sci Rep       Date:  2021-09-28       Impact factor: 4.379

10.  Evaluation of the sperm DNA fragmentation index in infertile Japanese men by in-house flow cytometric analysis.

Authors:  Akiyoshi Osaka; Hiroshi Okada; Sae Onozuka; Takashi Tanaka; Toshiyuki Iwahata; Yukihito Shimomura; Yoshitomo Kobori; Kazutaka Saito; Kouhei Sugimoto
Journal:  Asian J Androl       Date:  2022 Jan-Feb       Impact factor: 3.285
  10 in total

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