Literature DB >> 33925640

Microbiological Evaluation and Sperm DNA Fragmentation in Semen Samples of Patients Undergoing Fertility Investigation.

Chiara Pagliuca1, Federica Cariati2, Francesca Bagnulo3, Elena Scaglione1,4, Consolata Carotenuto1, Fabrizio Farina5, Valeria D'Argenio2,6, Francesca Carraturo1, Paola D'Aprile1, Mariateresa Vitiello1, Ida Strina3,7, Carlo Alviggi3,7,8, Roberta Colicchio1, Rossella Tomaiuolo9, Paola Salvatore1,2,10.   

Abstract

Fifteen percent of male infertility is associated with urogenital infections; several pathogens are able to alter the testicular and accessory glands' microenvironment, resulting in the impairment of biofunctional sperm parameters. The purpose of this study was to assess the influence of urogenital infections on the quality of 53 human semen samples through standard analysis, microbiological evaluation, and molecular characterization of sperm DNA damage. The results showed a significant correlation between infected status and semen volume, sperm concentration, and motility. Moreover, a high risk of fragmented sperm DNA was demonstrated in the altered semen samples. Urogenital infections are often asymptomatic and thus an in-depth evaluation of the seminal sample can allow for both the diagnosis and therapy of infections while providing more indicators for male infertility management.

Entities:  

Keywords:  male infertility; microbiological evaluation; sperm DNA fragmentation; urogenital infections

Year:  2021        PMID： 33925640     DOI： 10.3390/genes12050654

Source DB:  PubMed          Journal:  Genes (Basel)        ISSN： 2073-4425            Impact factor:   4.096


  47 in total

1.  Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa.

Authors:  G Barroso; M Morshedi; S Oehninger
Journal:  Hum Reprod       Date:  2000-06       Impact factor: 6.918

Review 2.  Sperm DNA damage assessment: a test whose time has come.

Authors:  Ashok Agarwal; Shyam S R Allamaneni
Journal:  Fertil Steril       Date:  2005-10       Impact factor: 7.329

Review 3.  Microbiological investigation in male infertility: a practical overview.

Authors:  Sandro La Vignera; Rosita A Condorelli; Enzo Vicari; Mario Salmeri; Giuseppe Morgia; Vincenzo Favilla; Sebastiano Cimino; Aldo E Calogero
Journal:  J Med Microbiol       Date:  2013-09-26       Impact factor: 2.472

4.  Sperm DNA fragmentation: threshold value in male fertility.

Authors:  M Sergerie; G Laforest; L Bujan; F Bissonnette; G Bleau
Journal:  Hum Reprod       Date:  2005-08-05       Impact factor: 6.918

5.  Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes.

Authors:  Luke Simon; Judit Castillo; Rafael Oliva; Sheena E M Lewis
Journal:  Reprod Biomed Online       Date:  2011-09-10       Impact factor: 3.828

Review 6.  Markers of semen inflammation: supplementary semen analysis?

Authors:  Sandro La Vignera; Rosita A Condorelli; Enzo Vicari; Dario Tumino; Giuseppe Morgia; Vincenzo Favilla; Sebastiano Cimino; Aldo E Calogero
Journal:  J Reprod Immunol       Date:  2013-07-10       Impact factor: 4.054

Review 7.  Genital tract infections and infertility.

Authors:  Donatella Pellati; Ioannis Mylonakis; Giulio Bertoloni; Cristina Fiore; Alessandra Andrisani; Guido Ambrosini; Decio Armanini
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2008-05-23       Impact factor: 2.435

Review 8.  Bacterial infection of the male reproductive system causing infertility.

Authors:  Marziye Farsimadan; Mohammad Motamedifar
Journal:  J Reprod Immunol       Date:  2020-08-03       Impact factor: 4.054

9.  Effects of tumour necrosis factor-alpha on human sperm motility and apoptosis.

Authors:  Anna Perdichizzi; Ferdinando Nicoletti; Sandro La Vignera; Nunziata Barone; Rosario D'Agata; Enzo Vicari; Aldo E Calogero; Aldo E E Calogero
Journal:  J Clin Immunol       Date:  2007-02-17       Impact factor: 8.542

Review 10.  Microbiota and Human Reproduction: The Case of Male Infertility.

Authors:  Rossella Tomaiuolo; Iolanda Veneruso; Federica Cariati; Valeria D'Argenio
Journal:  High Throughput       Date:  2020-04-13
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  5 in total

1.  Semen microbiota in normal and leukocytospermic males.

Authors:  Ye Yao; Xin-Jian Qiu; Dong-Sheng Wang; Jie-Kun Luo; Tao Tang; Yun-Hui Li; Chun-Hu Zhang; Hao Liu; Lu Zhou; Lin-Lin Zhao
Journal:  Asian J Androl       Date:  2022 Jul-Aug       Impact factor: 3.054

2.  The Impact of Bacteriocenoses on Sperm Vitality, Immunological and Oxidative Characteristics of Ram Ejaculates: Does the Breed Play a Role?

Authors:  Eva Tvrdá; Miroslava Kačániová; Andrej Baláži; Jaromír Vašíček; Jakub Vozaf; Rastislav Jurčík; Michal Ďuračka; Jana Žiarovská; Ján Kováč; Peter Chrenek
Journal:  Animals (Basel)       Date:  2021-12-28       Impact factor: 2.752

3.  Genetics and Genomics of Reproductive Medicine.

Authors:  Rossella Tomaiuolo
Journal:  Genes (Basel)       Date:  2021-10-14       Impact factor: 4.096

4.  Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study.

Authors:  Elena Scaglione; Giuseppe Mantova; Valeria Caturano; Luca Fanasca; Francesca Carraturo; Fabrizio Farina; Caterina Pagliarulo; Mariateresa Vitiello; Chiara Pagliuca; Paola Salvatore; Roberta Colicchio
Journal:  Diagnostics (Basel)       Date:  2022-07-25

Review 5.  Semen dysbiosis-just a male problem?

Authors:  Emilia Morawiec; Michał Czerwiński; Anna Bednarska- Czerwińska; Andrzej Wiczkowski
Journal:  Front Cell Infect Microbiol       Date:  2022-09-13       Impact factor: 6.073
  5 in total

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