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Literature DB >> 31297

Interaction of CDP-choline with synaptosomal transport of biogenic amines and their precursors in vitro and in vivo in the rat corpus striatum.

Abstract

Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10(-4) M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.) inhibits only the in vitro uptake of DA but enhances the uptake of precursors.

Entities: Chemical Gene Species

Mesh：

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Year: 1978 PMID： 31297 DOI： 10.1007/bf01922955

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

12 in total

1. METABOLISM OF (H3)NOREPINEPHRINE IN THE RAT BRAIN.

Authors: J GLOWINSKI; I J KOPIN; J AXELROD
Journal: J Neurochem Date: 1965-01 Impact factor: 5.372

2. Studies on the intrathecal pharmacotherapy. Part I: CDP-choline.

Authors: M Ogashiwa; K Takeuchi; M Hara; Y Tanaka; J Okada
Journal: Int J Clin Pharmacol Biopharm Date: 1975-10

3. Kinetics of serotonin accumulation into synaptosomes of rat brain--effects of amphetamine and chloroamphetamines.

Authors: D T Wong; J S Horng; R W Fuller
Journal: Biochem Pharmacol Date: 1973-02-01 Impact factor: 5.858

4. Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action.

Authors: J T Coyle; S H Snyder
Journal: Science Date: 1969-11-14 Impact factor: 47.728

5. Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.

Authors: E G Shaskan; S H Snyder
Journal: J Pharmacol Exp Ther Date: 1970-11 Impact factor: 4.030

6. Tryptophan transport across the synaptosomal membrane.

Authors: D G Grahame-Smith; A G Parfitt
Journal: J Neurochem Date: 1970-09 Impact factor: 5.372

7. Effect of neuroleptics and of combinations of d-amphetamine and neuroleptics on 3H-dopamine uptake by homogenates from rat striatum.

Authors: J Del Rio; J Madroñal
Journal: Eur J Pharmacol Date: 1976-10 Impact factor: 4.432

3. Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study.

Authors: Sujung J Yoon; In Kyoon Lyoo; Hengjun J Kim; Tae-Suk Kim; Young Hoon Sung; Namkug Kim; Scott E Lukas; Perry F Renshaw
Journal: Neuropsychopharmacology Date: 2009-12-30 Impact factor: 7.853

3 in total

Interaction of CDP-choline with synaptosomal transport of biogenic amines and their precursors in vitro and in vivo in the rat corpus striatum.

1. METABOLISM OF (H3)NOREPINEPHRINE IN THE RAT BRAIN.

2. Studies on the intrathecal pharmacotherapy. Part I: CDP-choline.

3. Kinetics of serotonin accumulation into synaptosomes of rat brain--effects of amphetamine and chloroamphetamines.

4. Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action.

5. Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.

6. Tryptophan transport across the synaptosomal membrane.

7. Effect of neuroleptics and of combinations of d-amphetamine and neuroleptics on 3H-dopamine uptake by homogenates from rat striatum.

8. Narcotic drugs: effects on the serotonin biosynthetic systems of the brain.

9. Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates.

10. Brain catechol synthesis: control by train tyrosine concentration.

1. Open-label uridine for treatment of depressed adolescents with bipolar disorder.

2. Uptake and utilization of CDP-choline in primary brain cell cultures from fetal brain.

3. Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study.