Literature DB >> 5345207

Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action.

J T Coyle, S H Snyder.   

Abstract

A variety of antiparkinsonian drugs are potent, noncompetitive inhibitors of dopamine uptake into synaptosomes in homogenates of rat corpus striatum. Inhibition of dopamine uptake may potentiate the synaptic actions of dopamine in the striatum and could explain the antiparkinsonian effects of these drugs. This hypothesis accounts for several clinical features of Parkinson's disease and predicts compounds which may be new therapeutic agents.

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Year:  1969        PMID： 5345207     DOI： 10.1126/science.166.3907.899

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  37 in total

1.  Effects of chlorimipramine on the synthesis and metabolism of dopamine in the rat striatum.

Authors:  S A Persson
Journal:  Psychopharmacology (Berl)       Date:  1979       Impact factor: 4.530

2.  Proceedings: Functional hyperaemia in soleus muscle of the cat.

Authors:  T Forrester; I J Hamilton
Journal:  J Physiol       Date:  1975-07       Impact factor: 5.182

3.  Human dopamine transporter gene: differential regulation of 18-kb haplotypes.

Authors:  Ying Zhao; Nian Xiong; Yang Liu; Yanhong Zhou; Nuomin Li; Hong Qing; Zhicheng Lin
Journal:  Pharmacogenomics       Date:  2013-09       Impact factor: 2.533

4.  Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain.

Authors:  H Tsukada; N Harada; S Nishiyama; H Ohba; T Kakiuchi
Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

5.  Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain.

Authors:  R Oishi; S Shishido; M Yamori; K Saeki
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-02       Impact factor: 3.000

6.  Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward.

Authors:  Erik B Oleson; Mark J Ferris; Rodrigo A España; Jill Harp; Sara R Jones
Journal:  Eur J Pharmacol       Date:  2012-03-15       Impact factor: 4.432

7.  Early sexual differentiation of diencephalic dopaminergic neurons of the rat in vitro.

Authors:  I Reisert; J Engele; C Pilgrim
Journal:  Cell Tissue Res       Date:  1989-02       Impact factor: 5.249

8.  Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice.

Authors:  Junzo Kamei; Kayo Morita; Shigeo Miyata; Kenji Onodera
Journal:  Psychopharmacology (Berl)       Date:  2003-01-21       Impact factor: 4.530

9.  Behavioral and biochemical studies of the scopolamine-induced reversal of neuroleptic activity.

Authors:  M G Ondrusek; C D Kilts; G D Frye; R B Mailman; R A Mueller; G R Breese
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

10.  Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices.

Authors:  Carrie E John; Sara R Jones
Journal:  Neuropharmacology       Date:  2007-03-16       Impact factor: 5.250
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