Literature DB >> 31288299

What role does the (2R,6R)-hydronorketamine metabolite play in the antidepressant-like and abuse-related effects of (R)-ketamine?

Todd M Hillhouse1, Remington Rice2, Joseph H Porter2.   

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Year:  2019        PMID： 31288299      PMCID： PMC6780034          DOI： 10.1111/bph.14785

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


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  22 in total

Review 1.  A brief history of the development of antidepressant drugs: from monoamines to glutamate.

Authors:  Todd M Hillhouse; Joseph H Porter
Journal:  Exp Clin Psychopharmacol       Date:  2015-02       Impact factor: 3.157

2.  Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

Authors:  Thu Ha Pham; Céline Defaix; Xiaoming Xu; Shi-Xian Deng; Nicolas Fabresse; Jean-Claude Alvarez; Donald W Landry; Rebecca A Brachman; Christine A Denny; Alain M Gardier
Journal:  Biol Psychiatry       Date:  2017-10-26       Impact factor: 13.382

3.  THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors.

Authors:  Stephen Ph Alexander; Arthur Christopoulos; Anthony P Davenport; Eamonn Kelly; Neil V Marrion; John A Peters; Elena Faccenda; Simon D Harding; Adam J Pawson; Joanna L Sharman; Christopher Southan; Jamie A Davies
Journal:  Br J Pharmacol       Date:  2017-12       Impact factor: 8.739

4.  What role does the (2R,6R)-hydronorketamine metabolite play in the antidepressant-like and abuse-related effects of (R)-ketamine?

Authors:  Todd M Hillhouse; Remington Rice; Joseph H Porter
Journal:  Br J Pharmacol       Date:  2019-08-17       Impact factor: 8.739

5.  (R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.

Authors:  Chun Yang; Youge Qu; Masahito Abe; Dai Nozawa; Shigeyuki Chaki; Kenji Hashimoto
Journal:  Biol Psychiatry       Date:  2016-12-23       Impact factor: 13.382

6.  (2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.

Authors:  Panos Zanos; Jaclyn N Highland; Brent W Stewart; Polymnia Georgiou; Carleigh E Jenne; Jacqueline Lovett; Patrick J Morris; Craig J Thomas; Ruin Moaddel; Carlos A Zarate; Todd D Gould
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-13       Impact factor: 11.205

7.  Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine.

Authors:  Jaclyn N Highland; Patrick J Morris; Panos Zanos; Jacqueline Lovett; Soumita Ghosh; Amy Q Wang; Carlos A Zarate; Craig J Thomas; Ruin Moaddel; Todd D Gould
Journal:  J Psychopharmacol       Date:  2018-11-29       Impact factor: 4.153

8.  Lack of metabolism in (R)-ketamine's antidepressant actions in a chronic social defeat stress model.

Authors:  Kai Zhang; Yuko Fujita; Kenji Hashimoto
Journal:  Sci Rep       Date:  2018-03-05       Impact factor: 4.379

9.  R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.

Authors:  C Yang; Y Shirayama; J-c Zhang; Q Ren; W Yao; M Ma; C Dong; K Hashimoto
Journal:  Transl Psychiatry       Date:  2015-09-01       Impact factor: 6.222

10.  Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.

Authors:  Yukihiko Shirayama; Kenji Hashimoto
Journal:  Int J Neuropsychopharmacol       Date:  2018-01-01       Impact factor: 5.176
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  3 in total

Review 1.  Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications.

Authors:  Jaclyn N Highland; Panos Zanos; Lace M Riggs; Polymnia Georgiou; Sarah M Clark; Patrick J Morris; Ruin Moaddel; Craig J Thomas; Carlos A Zarate; Edna F R Pereira; Todd D Gould
Journal:  Pharmacol Rev       Date:  2021-04       Impact factor: 25.468

2.  Correction.

Authors: 
Journal:  Br J Pharmacol       Date:  2020-07       Impact factor: 8.739

3.  What role does the (2R,6R)-hydronorketamine metabolite play in the antidepressant-like and abuse-related effects of (R)-ketamine?

Authors:  Todd M Hillhouse; Remington Rice; Joseph H Porter
Journal:  Br J Pharmacol       Date:  2019-08-17       Impact factor: 8.739
  3 in total

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