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Literature DB >> 28104224

(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.

Chun Yang¹, Youge Qu¹, Masahito Abe², Dai Nozawa², Shigeyuki Chaki², Kenji Hashimoto³.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2016 PMID： 28104224 DOI： 10.1016/j.biopsych.2016.12.020

Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382

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53 in total

1. Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model.

Authors: Kai Zhang; Hidetoh Toki; Yuko Fujita; Min Ma; Lijia Chang; Youge Qu; Shingo Harada; Tetsuhiro Nemoto; Akiko Mizuno-Yasuhira; Jun-Ichi Yamaguchi; Shigeyuki Chaki; Kenji Hashimoto
Journal: Psychopharmacology (Berl) Date: 2018-09-13 Impact factor: 4.530

2. Lack of dopamine D₁ receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model.

Authors: Lijia Chang; Kai Zhang; Yaoyu Pu; Youge Qu; Si-Ming Wang; Zhongwei Xiong; Yukihiko Shirayama; Kenji Hashimoto
Journal: Eur Arch Psychiatry Clin Neurosci Date: 2019-03-29 Impact factor: 5.270

Review 3. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Authors: Ronald S Duman; Gerard Sanacora; John H Krystal
Journal: Neuron Date: 2019-04-03 Impact factor: 17.173

(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.

1. Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model.

2. Lack of dopamine D₁ receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model.

Review 3. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Review 4. Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Review 5. Ketamine: The final frontier or another depressing end?

Review 6. Esketamine: a glimmer of hope in treatment-resistant depression.

Review 7. Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications.

Review 8. Convergent Mechanisms Underlying Rapid Antidepressant Action.

Review 9. Mechanisms of ketamine action as an antidepressant.

10. Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability.

(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.

1. Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model.

2. Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model.

Review 3. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Review 4. Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Review 5. Ketamine: The final frontier or another depressing end?

Review 6. Esketamine: a glimmer of hope in treatment-resistant depression.

Review 7. Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications.

Review 8. Convergent Mechanisms Underlying Rapid Antidepressant Action.

Review 9. Mechanisms of ketamine action as an antidepressant.

10. Sex differences in sub-anesthetic ketamine's antidepressant effects and abuse liability.

2. Lack of dopamine D₁ receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model.