Hoda Hatoum1, Pablo Maureira2, Scott Lilly3, Lakshmi Prasad Dasi4. 1. Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA. 2. Department of Cardiovascular Surgery, CHU de Nancy, Nancy, France. 3. Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA. 4. Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA. Electronic address: lakshmi.dasi@osumc.edu.
Abstract
BACKGROUND/ PURPOSE: This study aims at evaluating the impact of BASILICA on neo-sinus and sinus hemodynamics with and without coronary flow. Leaflet thrombosis after valve-in-valve (ViV) may compromise not only leaflet mobility but also affect valve durability and performance. METHODS/MATERIALS: In a 23 mm transparent surgical aortic valve model, a 23 mm Edwards SAPIEN 3 and a 26 mm Medtronic Evolut were deployed before and after leaflet laceration, in models with and without coronary flow. Neo-sinus and sinus hemodynamics were evaluated in the aortic position of a pulse duplicator and particle image velocimetry was performed in order to quantify sinus flow hemodynamics along with sinus and neo-sinus washout. RESULTS: BASILICA-type leaflet laceration procedure led to (a) an increase in the velocities in the sinus and the neo-sinus by 50% for Evolut ViV with and without coronary flow, 70% for non-coronary SAPIEN 3 ViV and 10% for coronary SAPIEN 3 ViV, and (b) an improvement in overall washout up to 2 cycles in the neo-sinus and 0.5 cycles in the sinus. CONCLUSIONS: A BASILICA-type leaflet laceration approach may improve sinus and neo-sinus hemodynamics through decreasing flow stasis and enabling less confined blood flow. BASILICA confers coronary sinus flow patterns to the non-coronary sinus.
BACKGROUND/ PURPOSE: This study aims at evaluating the impact of BASILICA on neo-sinus and sinus hemodynamics with and without coronary flow. Leaflet thrombosis after valve-in-valve (ViV) may compromise not only leaflet mobility but also affect valve durability and performance. METHODS/MATERIALS: In a 23 mm transparent surgical aortic valve model, a 23 mm Edwards SAPIEN 3 and a 26 mm Medtronic Evolut were deployed before and after leaflet laceration, in models with and without coronary flow. Neo-sinus and sinus hemodynamics were evaluated in the aortic position of a pulse duplicator and particle image velocimetry was performed in order to quantify sinus flow hemodynamics along with sinus and neo-sinus washout. RESULTS: BASILICA-type leaflet laceration procedure led to (a) an increase in the velocities in the sinus and the neo-sinus by 50% for Evolut ViV with and without coronary flow, 70% for non-coronary SAPIEN 3 ViV and 10% for coronary SAPIEN 3 ViV, and (b) an improvement in overall washout up to 2 cycles in the neo-sinus and 0.5 cycles in the sinus. CONCLUSIONS: A BASILICA-type leaflet laceration approach may improve sinus and neo-sinus hemodynamics through decreasing flow stasis and enabling less confined blood flow. BASILICA confers coronary sinus flow patterns to the non-coronary sinus.
Authors: Tarun Chakravarty; Lars Søndergaard; John Friedman; Ole De Backer; Daniel Berman; Klaus F Kofoed; Hasan Jilaihawi; Takahiro Shiota; Yigal Abramowitz; Troels H Jørgensen; Tanya Rami; Sharjeel Israr; Gregory Fontana; Martina de Knegt; Andreas Fuchs; Patrick Lyden; Alfredo Trento; Deepak L Bhatt; Martin B Leon; Raj R Makkar Journal: Lancet Date: 2017-03-19 Impact factor: 79.321
Authors: Hoda Hatoum; Milad Samaee; Janarthanan Sathananthan; Stephanie Sellers; Maximilian Kuetting; Scott M Lilly; Abdul R Ihdayhid; Philipp Blanke; Jonathon Leipsic; Vinod H Thourani; Lakshmi Prasad Dasi Journal: JTCVS Open Date: 2022-04-20