| Literature DB >> 31260703 |
Jim McBurney-Lin1, Ju Lu2, Yi Zuo3, Hongdian Yang4.
Abstract
The locus coeruleus-norepinephrine (LC-NE) system is involved in many brain functions and neurological disorders. In this review we discuss how LC-NE signaling affects the activity of cortical and subcortical sensory neurons, and how it influences perception-driven behaviors associated with mammalian somatosensory, visual, auditory, and olfactory systems. We summarize the consistent as well as seemingly inconsistent findings across brain areas and sensory modalities and propose a framework to understand these phenomena from the perspective of adrenergic receptor expression, dose-dependent physiology and excitation-inhibition balance. We also discuss potential future research directions in this field.Entities:
Keywords: Dose-dependent response; E/I balance; Locus coeruleus; Norepinephrine; Perception; Sensory processing; Signal-to-noise ratio
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Year: 2019 PMID： 31260703 PMCID： PMC6742544 DOI： 10.1016/j.neubiorev.2019.06.009
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989