Literature DB >> 9915705

The role of locus coeruleus in the regulation of cognitive performance.

M Usher1, J D Cohen, D Servan-Schreiber, J Rajkowski, G Aston-Jones.   

Abstract

Noradrenergic locus coeruleus (LC) neurons were recorded in monkeys performing a visual discrimination task, and a computational model was developed addressing the role of the LC brain system in cognitive performance. Changes in spontaneous and stimulus-induced patterns of LC activity correlated closely with fluctuations in behavioral performance. The model explains these fluctuations in terms of changes in electrotonic coupling among LC neurons and predicts improved performance during epochs of high coupling and synchronized LC firing. Cross correlations of simultaneously recorded LC neurons confirmed this prediction, indicating that electrotonic coupling in LC may play an important role in attentional modulation and the regulation of goal-directed versus exploratory behaviors.

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Year:  1999        PMID： 9915705     DOI： 10.1126/science.283.5401.549

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  211 in total

1.  Functional coupling between neurons and glia.

Authors:  V Alvarez-Maubecin; F Garcia-Hernandez; J T Williams; E J Van Bockstaele
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

2.  Electrical coupling and excitatory synaptic transmission between rhythmogenic respiratory neurons in the preBötzinger complex.

Authors:  J C Rekling; X M Shao; J L Feldman
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

3.  Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women.

Authors:  Gregory J Tranah; Terri Blackwell; Katie L Stone; Sonia Ancoli-Israel; Misti L Paudel; Kristine E Ensrud; Jane A Cauley; Susan Redline; Teresa A Hillier; Steven R Cummings; Kristine Yaffe
Journal:  Ann Neurol       Date:  2011-11       Impact factor: 10.422

4.  Dynamics of spiking neurons connected by both inhibitory and electrical coupling.

Authors:  Timothy J Lewis; John Rinzel
Journal:  J Comput Neurosci       Date:  2003 May-Jun       Impact factor: 1.621

5.  A computational model of anterior cingulate function in speeded response tasks: effects of frequency, sequence, and conflict.

Authors:  Andrew D Jones; Raymond Y Cho; Leigh E Nystrom; Jonathan D Cohen; Todd S Braver
Journal:  Cogn Affect Behav Neurosci       Date:  2002-12       Impact factor: 3.282

6.  The influence of spike rate and stimulus duration on noradrenergic neurons.

Authors:  Eric Brown; Jeff Moehlis; Philip Holmes; Ed Clayton; Janusz Rajkowski; Gary Aston-Jones
Journal:  J Comput Neurosci       Date:  2004 Jul-Aug       Impact factor: 1.621

7.  Compound stimulus presentation and the norepinephrine reuptake inhibitor atomoxetine enhance long-term extinction of cocaine-seeking behavior.

Authors:  Patricia H Janak; M Scott Bowers; Laura H Corbit
Journal:  Neuropsychopharmacology       Date:  2011-11-16       Impact factor: 7.853

Review 8.  Cannabinoid modulation of noradrenergic circuits: implications for psychiatric disorders.

Authors:  Ana Franky Carvalho; Elisabeth J Van Bockstaele
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2012-01-24       Impact factor: 5.067

9.  Hierarchical clustering of brain activity during human nonrapid eye movement sleep.

Authors:  Mélanie Boly; Vincent Perlbarg; Guillaume Marrelec; Manuel Schabus; Steven Laureys; Julien Doyon; Mélanie Pélégrini-Issac; Pierre Maquet; Habib Benali
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

10.  Thalamic noradrenaline in Parkinson's disease: deficits suggest role in motor and non-motor symptoms.

Authors:  Christian Pifl; Stephen J Kish; Oleh Hornykiewicz
Journal:  Mov Disord       Date:  2012-10-04       Impact factor: 10.338
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