Barbara Resnick1, N Jennifer Klinedinst2, Laura Yerges-Armstrong3, Jay Magaziner4, Denise Orwig4, Marc C Hochberg5, Ann L Gruber-Baldini4, Susan G Dorsey2. 1. University of Maryland School of Nursing, 655 West Lombard Street, Baltimore, MD 21201, USA. Electronic address: Resnick@son.umaryland.edu. 2. University of Maryland School of Nursing, 655 West Lombard Street, Baltimore, MD 21201, USA. 3. Program in Personalized Medicine, Division of Endocrinology, Department of Medicine, University of Maryland School of Medicine, 685 W. Baltimore St., Baltimore, MD 21201, USA. 4. University of Maryland, School of Medicine, Department of Epidemiology and Public Health, Baltimore, MD 21201, USA. 5. University of Maryland, School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA.
Abstract
BACKGROUND: Individuals who are resilient are more likely to engage in functional tasks and exercise post hip fracture. There may be a genetic predisposition to being resilient. OBJECTIVES: This study tested the direct and indirect association of 10 candidate genes, age, cognition, gender, comorbidities, pain and social activity on resilience, function and exercise post hip fracture. METHOD: This was a descriptive study including 172 community dwelling older adults. Measures included: age, gender, cognition (Modified Mini Mental Status Exam), comorbidities, social activities (self-report), DNA (GRM1, NTRK1, NTRK2, GNB3, NPY, SLC6A15. SLC6A4, BDNF, CR1TR1, FKBP5), pain (areas of pain and Numeric Rating Scale), function (Physical and Instrumental Activities of Daily Living; Lower Extremity Gains Score; Short Physical Performance Battery; Grip Strength) and exercise (Yale Physical Activity Scale). RESULTS: The majority of participants were Caucasian (93%), 50% were women and the average age was 81.09 (SD = 7.42). There were significant associations between resilience and single nucleotide polymorphisms from GRM1, NTRK1, NTRK2, GNB3, NPY and SLC6A15. Resilience, age, cognition, social activity, pain and genetic variability were directly and/or indirectly associated with exercise and/or function. DISCUSSION: This study highlights the importance of resilience for engagement in exercise and function after hip fracture and provides preliminary evidence for a genetic role for resilience.
BACKGROUND: Individuals who are resilient are more likely to engage in functional tasks and exercise post hip fracture. There may be a genetic predisposition to being resilient. OBJECTIVES: This study tested the direct and indirect association of 10 candidate genes, age, cognition, gender, comorbidities, pain and social activity on resilience, function and exercise post hip fracture. METHOD: This was a descriptive study including 172 community dwelling older adults. Measures included: age, gender, cognition (Modified Mini Mental Status Exam), comorbidities, social activities (self-report), DNA (GRM1, NTRK1, NTRK2, GNB3, NPY, SLC6A15. SLC6A4, BDNF, CR1TR1, FKBP5), pain (areas of pain and Numeric Rating Scale), function (Physical and Instrumental Activities of Daily Living; Lower Extremity Gains Score; Short Physical Performance Battery; Grip Strength) and exercise (Yale Physical Activity Scale). RESULTS: The majority of participants were Caucasian (93%), 50% were women and the average age was 81.09 (SD = 7.42). There were significant associations between resilience and single nucleotide polymorphisms from GRM1, NTRK1, NTRK2, GNB3, NPY and SLC6A15. Resilience, age, cognition, social activity, pain and genetic variability were directly and/or indirectly associated with exercise and/or function. DISCUSSION: This study highlights the importance of resilience for engagement in exercise and function after hip fracture and provides preliminary evidence for a genetic role for resilience.
Authors: Bengt B Arnetz; Sukhesh Sudan; Judith E Arnetz; Jolin B Yamin; Mark A Lumley; John S Beck; Paul M Stemmer; Paul Burghardt; Scott E Counts; Hikmet Jamil Journal: PLoS One Date: 2020-03-06 Impact factor: 3.240