Sofia Pugnaloni1, Arianna Vignini1, Francesca Borroni1, Jacopo Sabbatinelli1, Sonila Alia1, Mara Fabri2, Marina Taus3, Laura Mazzanti4, Rossana Berardi5. 1. Department of Clinical Sciences, Biology and Biochemistry Section, Università Politecnica delle Marche, Via Tronto 10/A, 60126, Ancona, Italy. 2. Department of Experimental and Clinical Medicine, Human Physiology Section, Università Politecnica delle Marche, Ancona, Italy. 3. Dietology and Clinical Nutrition, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona Umberto I Lancisi Salesi, Ancona, Italy. 4. Department of Clinical Sciences, Biology and Biochemistry Section, Università Politecnica delle Marche, Via Tronto 10/A, 60126, Ancona, Italy. lauramazzanti48@gmail.com. 5. Medical Oncology Clinic, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona Umberto I Lancisi Salesi, Ancona, Italy.
Abstract
PURPOSE: Taste changes due to chemotherapy may contribute to the high prevalence of malnutrition in cancer patients. It is believed that 50-70% of patients with cancer suffer from taste disorders. The aim of the present study was to analyze the taste alterations in patient population compared with that in controls, also in relation to gender. In this way, it could open to a new approach for a personalized diet to prevent and/or reduce taste alterations and malnutrition in cancer patients. METHODS: Forty-five cancer patients undergoing chemotherapy were compared with healthy controls (n = 32). Taste function test was used to determine taste sensitivity. Different concentrations for each of the four basic tastes (salty, sweet, sour, bitter) and also fat and water tastes were evaluated. RESULTS: A significant difference in taste sensitivity between patients and control group was found, in line with previous similar studies. As in the control group, taste perception in patients was better in females than in males, suggesting interaction effect between group and gender. CONCLUSIONS: Coping strategies regarding subjective taste impairment should be provided since alterations in taste sensitivity influence food preferences and appetite. Clinicians could thus have the potential to underpin changes in dietary intake and consequently in nutritional status; understanding the extent of the contribution of each taste would help in the development of effective interventions in future. Consequently, patients can adopt appropriate appetizing strategies and, based on that, change their feeding habits.
PURPOSE: Taste changes due to chemotherapy may contribute to the high prevalence of malnutrition in cancerpatients. It is believed that 50-70% of patients with cancer suffer from taste disorders. The aim of the present study was to analyze the taste alterations in patient population compared with that in controls, also in relation to gender. In this way, it could open to a new approach for a personalized diet to prevent and/or reduce taste alterations and malnutrition in cancerpatients. METHODS: Forty-five cancerpatients undergoing chemotherapy were compared with healthy controls (n = 32). Taste function test was used to determine taste sensitivity. Different concentrations for each of the four basic tastes (salty, sweet, sour, bitter) and also fat and water tastes were evaluated. RESULTS: A significant difference in taste sensitivity between patients and control group was found, in line with previous similar studies. As in the control group, taste perception in patients was better in females than in males, suggesting interaction effect between group and gender. CONCLUSIONS: Coping strategies regarding subjective taste impairment should be provided since alterations in taste sensitivity influence food preferences and appetite. Clinicians could thus have the potential to underpin changes in dietary intake and consequently in nutritional status; understanding the extent of the contribution of each taste would help in the development of effective interventions in future. Consequently, patients can adopt appropriate appetizing strategies and, based on that, change their feeding habits.
Entities:
Keywords:
Chemosensory; Chemotherapy; Gender; Malnutrition; Quality of life
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