Christian A Barrera1, Maria A Bedoya1,2, Jorge Delgado1,3, Jeffrey I Berman1,2, Nancy A Chauvin4, J Christopher Edgar1,2, Diego Jaramillo5. 1. Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. 2. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3. Department of Radiology, Massachusetts General Hospital, Boston, MA, USA. 4. Department of Radiology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA. 5. Department of Radiology, Columbia University Medical Center, 630 W. 168th St., MC 28, New York, NY, 10032, USA. dj2521@cumc.columbia.edu.
Abstract
BACKGROUND: Diffusion-tensor imaging (DTI) depicts the movement of water through columns of cartilage and newly formed bone and provides information about velocity of growth and growth potential. OBJECTIVE: To determine the correlation between DTI tractography parameters of the distal femoral physis and metaphysis and the height change after DTI in pubertal and post-pubertal children. MATERIALS AND METHODS: We retrospectively analyzed DTI images of the knee in 47 children with a mean age of 14.1 years in a 2-year period. In sagittal echoplanar DTI studies, regions of interest were placed in the femoral physis. Tractography was performed using a fractional anisotropy threshold of 0.15 and a maximum turning angle of 40°. The sample was divided to assess short-term and long-term growth after DTI. Short-term growth (n=25) was the height change between height at MRI and 1 year later. Long-term growth (n=36) was the height gain between height at MRI and at the growth plateau. RESULTS: For the short-term group, subjects with larger tract volume (R2=0.40) and longer track lengths (R2=0.38) had larger height gains (P<0.01). For the long-term group, subjects with larger tract volume (R2=0.43) and longer track lengths (R2=0.32) had a larger height gain at the growth plateau (P<0.01). Intra- and inter-observer variability were good-excellent. CONCLUSION: Follow-up data of growth 1 year after DTI evaluation and at skeletal maturity confirms that DTI parameters are associated with the amount of post-imaging growth.
BACKGROUND: Diffusion-tensor imaging (DTI) depicts the movement of water through columns of cartilage and newly formed bone and provides information about velocity of growth and growth potential. OBJECTIVE: To determine the correlation between DTI tractography parameters of the distal femoral physis and metaphysis and the height change after DTI in pubertal and post-pubertal children. MATERIALS AND METHODS: We retrospectively analyzed DTI images of the knee in 47 children with a mean age of 14.1 years in a 2-year period. In sagittal echoplanar DTI studies, regions of interest were placed in the femoral physis. Tractography was performed using a fractional anisotropy threshold of 0.15 and a maximum turning angle of 40°. The sample was divided to assess short-term and long-term growth after DTI. Short-term growth (n=25) was the height change between height at MRI and 1 year later. Long-term growth (n=36) was the height gain between height at MRI and at the growth plateau. RESULTS: For the short-term group, subjects with larger tract volume (R2=0.40) and longer track lengths (R2=0.38) had larger height gains (P<0.01). For the long-term group, subjects with larger tract volume (R2=0.43) and longer track lengths (R2=0.32) had a larger height gain at the growth plateau (P<0.01). Intra- and inter-observer variability were good-excellent. CONCLUSION: Follow-up data of growth 1 year after DTI evaluation and at skeletal maturity confirms that DTI parameters are associated with the amount of post-imaging growth.
Authors: Maria A Bedoya; Jorge Delgado; Jeffrey I Berman; Nancy A Chauvin; David Zurakowski; Raul Ramirez-Grueso; Aikaterini Ntoulia; Diego Jaramillo Journal: Radiology Date: 2017-02-02 Impact factor: 11.105
Authors: Nian Wang; Anthony J Mirando; Gary Cofer; Yi Qi; Matthew J Hilton; G Allan Johnson Journal: Magn Reson Med Date: 2019-01-22 Impact factor: 4.668
Authors: P Cohen; A D Rogol; C L Deal; P Saenger; E O Reiter; J L Ross; S D Chernausek; M O Savage; J M Wit Journal: J Clin Endocrinol Metab Date: 2008-09-09 Impact factor: 5.958
Authors: Diego Jaramillo; Phuong Duong; Jie C Nguyen; Sogol Mostoufi-Moab; Michael K Nguyen; Andrew Moreau; Christian A Barrera; Shijie Hong; José G Raya Journal: Radiology Date: 2022-03-22 Impact factor: 29.146
Authors: Nian Wang; Anthony J Mirando; Gary Cofer; Yi Qi; Matthew J Hilton; G Allan Johnson Journal: Magn Reson Med Date: 2020-01-21 Impact factor: 4.668