Phuong Duong1, Sogol Mostoufi-Moab2, José G Raya3, Camilo Jaimes4, Jorge Delgado5, Diego Jaramillo1. 1. Department of Radiology, Columbia University Medical Center, New York, New York, USA. 2. Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. 3. Department of Radiology, NYU Langone Medical Center, New York, New York, USA. 4. Department of Radiology, Boston Children's Hospital, Boston, Massachusetts, USA. 5. Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abstract
BACKGROUND: Current methods to predict height and growth failure are imprecise. MRI measures of physeal cartilage are promising biomarkers for growth. PURPOSE: In the physis, to assess how 3D MRI volume measurements, and diffusion tensor imaging (DTI) measurements (tract volume and length) correlate with growth parameters and detect differences in growth. We compared patients exposed to cis-retinoic acid, which causes physeal damage and growth failure, with normal subjects. STUDY TYPE: Case-control. POPULATION: Twenty pediatric neuroblastoma survivors treated with cis-retinoic acid and 20 age- and sex-matched controls. FIELD STRENGTH/SEQUENCE: 3T; DTI and 3D double-echo steady-state (DESS) sequences. ASSESSMENT: On distal femoral MR studies, physeal 3D volume and DTI tract measurements were calculated and compared to height. STATISTICAL TESTS: We used partial Spearman correlation, analysis of covariance, logistic regression, Wald test, and the intraclass correlation coefficient (ICC). RESULTS: The height percentile correlated most strongly with DTI tract volumes (r = 0.74), followed by mean tract length (r = 0.53) and 3D volume (r = 0.40) (all P < 0.02). Only tract volumes and lengths correlated with annualized growth velocity. Relative to controls, patients showed smaller tract volumes (8.00 cc vs. 13.71 cc, P < 0.01), shorter tract lengths (5.92 mm vs 6.99 mm, P = 0.03), and smaller ratios of 3D cartilage volume to tract length; but no difference (4.51 cc vs 4.85 cc) in 3D MRI volumes. The 10 patients with the lowest height percentiles had smaller tract volumes (5.07 cc vs. 10.93 cc, P < 0.01), but not significantly different 3D MRI volumes. Tract volume is associated with abnormal growth, with an accuracy of 75%. DATA CONCLUSION: DTI tract volume of the physis/metaphysis predicts abnormal growth better than physeal cartilage volumetric measurement and correlates best with height percentile and growth velocity. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2 J. Magn. Reson. Imaging 2020;52:544-551.
BACKGROUND: Current methods to predict height and growth failure are imprecise. MRI measures of physeal cartilage are promising biomarkers for growth. PURPOSE: In the physis, to assess how 3D MRI volume measurements, and diffusion tensor imaging (DTI) measurements (tract volume and length) correlate with growth parameters and detect differences in growth. We compared patients exposed to cis-retinoic acid, which causes physeal damage and growth failure, with normal subjects. STUDY TYPE: Case-control. POPULATION: Twenty pediatric neuroblastoma survivors treated with cis-retinoic acid and 20 age- and sex-matched controls. FIELD STRENGTH/SEQUENCE: 3T; DTI and 3D double-echo steady-state (DESS) sequences. ASSESSMENT: On distal femoral MR studies, physeal 3D volume and DTI tract measurements were calculated and compared to height. STATISTICAL TESTS: We used partial Spearman correlation, analysis of covariance, logistic regression, Wald test, and the intraclass correlation coefficient (ICC). RESULTS: The height percentile correlated most strongly with DTI tract volumes (r = 0.74), followed by mean tract length (r = 0.53) and 3D volume (r = 0.40) (all P < 0.02). Only tract volumes and lengths correlated with annualized growth velocity. Relative to controls, patients showed smaller tract volumes (8.00 cc vs. 13.71 cc, P < 0.01), shorter tract lengths (5.92 mm vs 6.99 mm, P = 0.03), and smaller ratios of 3D cartilage volume to tract length; but no difference (4.51 cc vs 4.85 cc) in 3D MRI volumes. The 10 patients with the lowest height percentiles had smaller tract volumes (5.07 cc vs. 10.93 cc, P < 0.01), but not significantly different 3D MRI volumes. Tract volume is associated with abnormal growth, with an accuracy of 75%. DATA CONCLUSION: DTI tract volume of the physis/metaphysis predicts abnormal growth better than physeal cartilage volumetric measurement and correlates best with height percentile and growth velocity. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2 J. Magn. Reson. Imaging 2020;52:544-551.
Authors: Christian A Barrera; Maria A Bedoya; Jorge Delgado; Jeffrey I Berman; Nancy A Chauvin; J Christopher Edgar; Diego Jaramillo Journal: Pediatr Radiol Date: 2019-06-08
Authors: David D Martin; Jan M Wit; Ze'ev Hochberg; Lars Sävendahl; Rick R van Rijn; Oliver Fricke; Noël Cameron; Janina Caliebe; Thomas Hertel; Daniela Kiepe; Kerstin Albertsson-Wikland; Hans Henrik Thodberg; Gerhard Binder; Michael B Ranke Journal: Horm Res Paediatr Date: 2011-06-21 Impact factor: 2.852
Authors: Jorge Delgado; Diego Jaramillo; Nancy A Chauvin; Michelle Guo; Mackenzie S Stratton; Hannah E Sweeney; Christian A Barrera; Sogol Mostoufi-Moab Journal: Pediatr Radiol Date: 2019-05-04