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Literature DB >> 31163387

Genetic evidence for the role of transforming growth factor-β in atopic phenotypes.

Katherine A Weissler¹, Pamela A Frischmeyer-Guerrerio².

Abstract

New evidence in humans and mice supports a role for transforming growth factor-β (TGF-β) in the initiation and effector phases of allergic disease, as well as in consequent tissue dysfunction. This pleiotropic cytokine can affect T cell activation and differentiation and B cell immunoglobulin class switching following initial encounter with an allergen. TGF-β can also act on mast cells during an acute allergic episode to modulate the strength of the response, in addition to driving tissue remodeling following damage caused by an allergic attack. Accordingly, genetic disorders leading to altered TGF-β signaling can result in increased rates of allergic disease. Published by Elsevier Ltd.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2019 PMID： 31163387 PMCID： PMC6800617 DOI： 10.1016/j.coi.2019.05.002

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

115 in total

1. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7.

Authors: Massimo C Fantini; Christoph Becker; Giovanni Monteleone; Francesco Pallone; Peter R Galle; Markus F Neurath
Journal: J Immunol Date: 2004-05-01 Impact factor: 5.422

2. Oral tolerance in the absence of naturally occurring Tregs.

Authors: Daniel Mucida; Nino Kutchukhidze; Agustin Erazo; Momtchilo Russo; Juan J Lafaille; Maria A Curotto de Lafaille
Journal: J Clin Invest Date: 2005-06-02 Impact factor: 14.808

3. α_S1-Casein elucidate major T-cell responses in cow's milk allergy.

Authors: L Diego Archila; Fatima S Khan; Nupur Bhatnagar; David Robinson; Mary L Farrington; William W Kwok
Journal: J Allergy Clin Immunol Date: 2017-03-23 Impact factor: 10.793

4. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.

Authors: C L Bennett; J Christie; F Ramsdell; M E Brunkow; P J Ferguson; L Whitesell; T E Kelly; F T Saulsbury; P F Chance; H D Ochs
Journal: Nat Genet Date: 2001-01 Impact factor: 38.330

Review 5. From interleukin-9 to T helper 9 cells.

Authors: Michael Stassen; Edgar Schmitt; Tobias Bopp
Journal: Ann N Y Acad Sci Date: 2012-01-11 Impact factor: 5.691

6. TGF-beta1 inhibits the release of histamine and tumor necrosis factor-alpha from mast cells through an autocrine pathway.

Authors: E Y Bissonnette; J A Enciso; A D Befus
Journal: Am J Respir Cell Mol Biol Date: 1997-03 Impact factor: 6.914

7. Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5(-) T(H)2 responses.

Authors: Calman Prussin; Joohee Lee; Barbara Foster
Journal: J Allergy Clin Immunol Date: 2009-12 Impact factor: 10.793

8. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

Authors: Marc Veldhoen; Catherine Uyttenhove; Jacques van Snick; Helena Helmby; Astrid Westendorf; Jan Buer; Bruno Martin; Christoph Wilhelm; Brigitta Stockinger
Journal: Nat Immunol Date: 2008-10-19 Impact factor: 25.606

Genetic evidence for the role of transforming growth factor-β in atopic phenotypes.

1. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7.

2. Oral tolerance in the absence of naturally occurring Tregs.

3. α_S1-Casein elucidate major T-cell responses in cow's milk allergy.

4. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.

Review 5. From interleukin-9 to T helper 9 cells.

6. TGF-beta1 inhibits the release of histamine and tumor necrosis factor-alpha from mast cells through an autocrine pathway.

7. Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5(-) T(H)2 responses.

8. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

9. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma.

Review 10. Reevaluation of Pluripotent Cytokine TGF-β3 in Immunity.

Review 1. Women in immunology: 2020 and beyond.

Review 2. Intestinal immunoregulation: lessons from human mendelian diseases.

Review 3. The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.