M A Boyanov1. 1. University Hospital Alexandrovska, Clinic of Endocrinology and Metabolic Diseases, Medical University of Sofia, Faculty of Medicine, Department of Internal Medicine, Sofia, Bulgaria.
Abstract
BACKGROUND: Dual-energy X-ray absorptiometry (DXA) allows measurement of whole body (WB) and regional bone mineral content (BMC) and density (BMD). OBJECTIVE: To measure WB and regional bone area, BMC and BMD (arms, legs, ribs and pelvis) in women of different ages. SUBJECTS AND METHODS: 140 women participated (age range 20-75 yrs). Three subgroups were built: 20-44 yr (30 premenopausal women), 45-59 (80 women), and 60-75 (30 women). WB DXA was performed on a Hologic QDR 4500 A bone densitometer (Hologic Inc., Bedford MA). WB BMD T-scores were calculated by using the manufacturer-provided and the NHANES 1999-2004 reference databases, while the WB BMC Z-scores - based on the latter. Statistical analysis was performed on an IBM SPSS Statistics 19.0 for Windows platform (Chicago, IL). RESULTS: WB BMC and BMD Z-scores were consistently lower than the reference databases showing a difference of about 0.4 - 0.5 SD. The arms, legs and ribs lost more BMC after the age of 50-55, while the pelvis - much earlier. The total decreases in BMC were highest in the pelvis (26.36 %), followed by the arms (16.81 %) and whole body (15.91 %), while the bone area decreased mostly in the pelvis (13.23 %). CONCLUSION: The age-related declines in regional BMC, bone areas and BMD follow different patterns in appendicular and axial bones.
BACKGROUND: Dual-energy X-ray absorptiometry (DXA) allows measurement of whole body (WB) and regional bone mineral content (BMC) and density (BMD). OBJECTIVE: To measure WB and regional bone area, BMC and BMD (arms, legs, ribs and pelvis) in women of different ages. SUBJECTS AND METHODS: 140 women participated (age range 20-75 yrs). Three subgroups were built: 20-44 yr (30 premenopausal women), 45-59 (80 women), and 60-75 (30 women). WB DXA was performed on a Hologic QDR 4500 A bone densitometer (Hologic Inc., Bedford MA). WB BMD T-scores were calculated by using the manufacturer-provided and the NHANES 1999-2004 reference databases, while the WB BMC Z-scores - based on the latter. Statistical analysis was performed on an IBM SPSS Statistics 19.0 for Windows platform (Chicago, IL). RESULTS: WB BMC and BMD Z-scores were consistently lower than the reference databases showing a difference of about 0.4 - 0.5 SD. The arms, legs and ribs lost more BMC after the age of 50-55, while the pelvis - much earlier. The total decreases in BMC were highest in the pelvis (26.36 %), followed by the arms (16.81 %) and whole body (15.91 %), while the bone area decreased mostly in the pelvis (13.23 %). CONCLUSION: The age-related declines in regional BMC, bone areas and BMD follow different patterns in appendicular and axial bones.
Entities:
Keywords:
Dual-energy X-ray absorptiometry; bone mineral content; bone mineral density; regional; whole body
Authors: Amanda R Vest; William W Wong; Joronia Chery; Alex Coston; Laura Telfer; Matthew Lawrence; Didjana Celkupa; Michael S Kiernan; Gregory Couper; Masashi Kawabori; Edward Saltzman Journal: Circ Heart Fail Date: 2022-04-05 Impact factor: 10.447