Gossypol interferes selectively with water and urea permeability of toad bladder.

Gossypol, a polyphenol compound with antifertility properties in human male, has been found to interfere with the response of toad bladder to vasopressin in terms of permeability to water and to urea; on the other hand, ion movement is spared for several hours as judged from short-circuit current and conductance data. Action of the drug lies distal to the generation of cyclic AMP since bladder hydrosmotic response to the latter was affected to the same extent as when the hormone was applied.