| Literature DB >> 2421770 |
M Kanje, P Ekström, J Deinum, M Wallin.
Abstract
Gossypol at micromolar concentrations (2 microM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 microM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin.Entities:
Keywords: Animals, Laboratory; Clinical Research; Contraception; Contraception Research; Contraceptive Agents, Male--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Family Planning; Gossypol--pharmacodynamics; Male Contraception; Research Methodology
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Year: 1986 PMID： 2421770 DOI： 10.1016/0005-2736(86)90134-3
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002