Literature DB >> 6862017

Gossypol binds to a high-affinity binding site on human serum albumin.

R E Royer, D L Vander Jagt.   

Abstract

The triterpene gossypol competes with bilirubin for a high-affinity binding site on human serum albumin. Similar competition between bilirubin and gossypol occurs in the binding of these ligands to the glutathione S-transferases from human liver and placenta. In each case, gossypol and bilirubin exhibit similar binding constants. The binding properties of gossypol may generally mimic those of bilirubin.

Entities:  

Keywords:  Biology; Contraception; Contraception Research; Examinations And Diagnoses; Family Planning; Hepatic Effects; Laboratory Examinations And Diagnoses; Laboratory Procedures; Male Contraception; Physiology

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Year:  1983        PMID： 6862017     DOI： 10.1016/0014-5793(83)81109-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Gossypol interferes selectively with water and urea permeability of toad bladder.

Authors:  V Beaujean; J Crabbé
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657

2.  Effect of replacing soybean meal with cottonseed meal on growth, hematology, antioxidant enzymes activity and expression for juvenile grass carp, Ctenopharyngodon idellus.

Authors:  Qingmei Zheng; Xiaobo Wen; Chunyan Han; Haobo Li; Xiaohui Xie
Journal:  Fish Physiol Biochem       Date:  2012-08       Impact factor: 2.794

3.  Gossypol-induced damage to mitochondria of transformed Sertoli cells.

Authors:  J M Robinson; N Tanphaichitr; A R Bellvé
Journal:  Am J Pathol       Date:  1986-12       Impact factor: 4.307

4.  In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes.

Authors:  S K Kulp; Y Rikihisa; Y C Lin; P P Moh; P K Li; Y Gu
Journal:  Parasitol Res       Date:  1993       Impact factor: 2.289

5.  A free cysteine prolongs the half-life of a homing peptide and improves its tumor-penetrating activity.

Authors:  Hong-Bo Pang; Gary B Braun; Zhi-Gang She; Venkata R Kotamraju; Kazuki N Sugahara; Tambet Teesalu; Erkki Ruoslahti
Journal:  J Control Release       Date:  2013-12-15       Impact factor: 9.776

6.  Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats.

Authors:  Ritu Aneja; Sujata K Dass; Ramesh Chandra
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2003 Jul-Sep       Impact factor: 2.441

7.  Development of an RP-UHPLC-PDA method for quantification of free gossypol in cottonseed cake and fungal-treated cottonseed cake.

Authors:  Aparecido Almeida Conceição; Clemente Batista Soares Neto; José Antônio de Aquino Ribeiro; Felix Gonçalves de Siqueira; Robert Neil Gerard Miller; Simone Mendonça
Journal:  PLoS One       Date:  2018-05-23       Impact factor: 3.240

8.  Effects of cottonseed meal on growth performance, liver redox status, and serum biochemical parameters in goslings at 1 to 28 days of age.

Authors:  Jun Yu; Zhengfeng Yang; Haiming Yang; Zhiyue Wang
Journal:  BMC Vet Res       Date:  2022-09-15       Impact factor: 2.792

9.  The Biological Effects of Bilirubin Photoisomers.

Authors:  Jana Jasprova; Matteo Dal Ben; Eleonora Vianello; Iryna Goncharova; Marie Urbanova; Karolina Vyroubalova; Silvia Gazzin; Claudio Tiribelli; Martin Sticha; Marcela Cerna; Libor Vitek
Journal:  PLoS One       Date:  2016-02-01       Impact factor: 3.240
  9 in total

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