Monica Pentenero1, Leah M Bowers2, Ruwan Jayasinghe3, Tami Yap4, Sok Ching Cheong5, Alexander Ross Kerr6, Camile S Farah7, Ilias Alevizos8. 1. Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin, Turin, Italy. 2. Department of Stomatology, Division of Oral Medicine, Medical University of South Carolina, Charleston, SC, USA. 3. Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. 4. Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia. 5. Head and Neck Cancer Research Team, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. 6. New York University College of Dentistry, New York, NY, USA. 7. Australian Centre for Oral Oncology Research & Education, UWA Dental School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia. 8. Sjogren's Syndrome and Salivary Gland Dysfunction Unit, NIDCR/NIH, Bethesda, MD, USA.
Abstract
BACKGROUND: Long non-coding RNAs (lncRNAs) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lncRNAs is implicated in cancer initiation, progression and metastasis. OBJECTIVES: To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lncRNAs in oral/tongue squamous cell carcinoma. METHODS: PubMed, Scopus and Web of Science were used as search engines. Clinical, full-length, English language studies were included. PRISMA-ScR protocol was used to evaluate and present results. The present scoping review summarizes relationships of the differential expression of lncRNAs with the presence of tumour and with clinicopathological features including survival. RESULTS: Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lncRNAs. CONCLUSIONS: Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.
BACKGROUND: Long non-coding RNAs (lncRNAs) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lncRNAs is implicated in cancer initiation, progression and metastasis. OBJECTIVES: To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lncRNAs in oral/tongue squamous cell carcinoma. METHODS: PubMed, Scopus and Web of Science were used as search engines. Clinical, full-length, English language studies were included. PRISMA-ScR protocol was used to evaluate and present results. The present scoping review summarizes relationships of the differential expression of lncRNAs with the presence of tumour and with clinicopathological features including survival. RESULTS: Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lncRNAs. CONCLUSIONS: Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.
Authors: Ewan A Gibb; Katey S S Enfield; Greg L Stewart; Kim M Lonergan; Raj Chari; Raymond T Ng; Lewei Zhang; Calum E MacAulay; Miriam P Rosin; Wan L Lam Journal: Oral Oncol Date: 2011-08-10 Impact factor: 5.337
Authors: Gokce A Toruner; Celal Ulger; Mualla Alkan; Anthony T Galante; Joseph Rinaggio; Randall Wilk; Bin Tian; Patricia Soteropoulos; Meera R Hameed; Marvin N Schwalb; James J Dermody Journal: Cancer Genet Cytogenet Date: 2004-10-01
Authors: Hui Ye; Tianwei Yu; Stephane Temam; Barry L Ziober; Jianguang Wang; Joel L Schwartz; Li Mao; David T Wong; Xiaofeng Zhou Journal: BMC Genomics Date: 2008-02-06 Impact factor: 3.969
Authors: Cherry L Estilo; Pornchai O-charoenrat; Simon Talbot; Nicholas D Socci; Diane L Carlson; Ronald Ghossein; Tijaana Williams; Yoshihiro Yonekawa; Yegnanarayana Ramanathan; Jay O Boyle; Dennis H Kraus; Snehal Patel; Ashok R Shaha; Richard J Wong; Joseph M Huryn; Jatin P Shah; Bhuvanesh Singh Journal: BMC Cancer Date: 2009-01-12 Impact factor: 4.430
Authors: Alayne L Brunner; Andrew H Beck; Badreddin Edris; Robert T Sweeney; Shirley X Zhu; Rui Li; Kelli Montgomery; Sushama Varma; Thea Gilks; Xiangqian Guo; Joseph W Foley; Daniela M Witten; Craig P Giacomini; Ryan A Flynn; Jonathan R Pollack; Robert Tibshirani; Howard Y Chang; Matt van de Rijn; Robert B West Journal: Genome Biol Date: 2012-08-28 Impact factor: 13.583