Literature DB >> 31138566

Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.

Roger V Ortines1, Yu Wang1, Haiyun Liu1, Dustin A Dikeman1, Bret L Pinsker1, Robert J Miller1, Sophia E Kim1, Nicole E Ackerman1, Joe F Rizkallah1, LeeAnn T Marcello1, Taylor S Cohen2, Christine Tkaczyk2, Bret R Sellman2, Lloyd S Miller3,4,5,6.   

Abstract

Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  ClfA; MRSA; Staphylococcus aureuszzm321990; alpha-toxin; clumping factor A; hla; leukocidin; surgical

Mesh：

Substances：

Year:  2019        PMID： 31138566      PMCID： PMC6658795          DOI： 10.1128/AAC.00346-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus.

Authors:  Noe Reyes; Robert Skinner; Bret M Benton; Kevin M Krause; Josephine Shelton; Glenmar P Obedencio; Sharath S Hegde
Journal:  J Antimicrob Chemother       Date:  2006-05-30       Impact factor: 5.790

2.  New WHO recommendations on preoperative measures for surgical site infection prevention: an evidence-based global perspective.

Authors:  Benedetta Allegranzi; Peter Bischoff; Stijn de Jonge; N Zeynep Kubilay; Bassim Zayed; Stacey M Gomes; Mohamed Abbas; Jasper J Atema; Sarah Gans; Miranda van Rijen; Marja A Boermeester; Matthias Egger; Jan Kluytmans; Didier Pittet; Joseph S Solomkin
Journal:  Lancet Infect Dis       Date:  2016-11-02       Impact factor: 25.071

3.  Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency.

Authors:  C Tkaczyk; L Hua; R Varkey; Y Shi; L Dettinger; R Woods; A Barnes; R S MacGill; S Wilson; P Chowdhury; C K Stover; B R Sellman
Journal:  Clin Vaccine Immunol       Date:  2012-01-11

4.  Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets.

Authors:  Yu Wang; Lily I Cheng; David R Helfer; Alyssa G Ashbaugh; Robert J Miller; Alexander J Tzomides; John M Thompson; Roger V Ortines; Andrew S Tsai; Haiyun Liu; Carly A Dillen; Nathan K Archer; Taylor S Cohen; Christine Tkaczyk; C Kendall Stover; Bret R Sellman; Lloyd S Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-12       Impact factor: 11.205

5.  Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011-2014.

Authors:  Lindsey M Weiner; Amy K Webb; Brandi Limbago; Margaret A Dudeck; Jean Patel; Alexander J Kallen; Jonathan R Edwards; Dawn M Sievert
Journal:  Infect Control Hosp Epidemiol       Date:  2016-08-30       Impact factor: 3.254

6.  Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017.

Authors:  Sandra I Berríos-Torres; Craig A Umscheid; Dale W Bratzler; Brian Leas; Erin C Stone; Rachel R Kelz; Caroline E Reinke; Sherry Morgan; Joseph S Solomkin; John E Mazuski; E Patchen Dellinger; Kamal M F Itani; Elie F Berbari; John Segreti; Javad Parvizi; Joan Blanchard; George Allen; Jan A J W Kluytmans; Rodney Donlan; William P Schecter
Journal:  JAMA Surg       Date:  2017-08-01       Impact factor: 14.766

7.  Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.

Authors:  C Tkaczyk; S Kasturirangan; A Minola; O Jones-Nelson; V Gunter; Y Y Shi; K Rosenthal; V Aleti; E Semenova; P Warrener; D Tabor; C K Stover; D Corti; G Rainey; B R Sellman
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

8.  Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.

Authors:  Julie E Pickett; John M Thompson; Agnieszka Sadowska; Christine Tkaczyk; Bret R Sellman; Andrea Minola; Davide Corti; Antonio Lanzavecchia; Lloyd S Miller; Daniel Lj Thorek
Journal:  Bone Res       Date:  2018-04-25       Impact factor: 13.567

9.  Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging.

Authors:  Roger D Plaut; Christopher P Mocca; Ranjani Prabhakara; Tod J Merkel; Scott Stibitz
Journal:  PLoS One       Date:  2013-03-12       Impact factor: 3.240

10.  Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.

Authors:  Francisco Romero Pastrana; John M Thompson; Marjolein Heuker; Hedzer Hoekstra; Carly A Dillen; Roger V Ortines; Alyssa G Ashbaugh; Julie E Pickett; Matthijs D Linssen; Nicholas M Bernthal; Kevin P Francis; Girbe Buist; Marleen van Oosten; Gooitzen M van Dam; Daniel L J Thorek; Lloyd S Miller; Jan Maarten van Dijl
Journal:  Virulence       Date:  2017-12-26       Impact factor: 5.882
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  7 in total

1.  Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

Authors:  Trang T T Vu; Nhu T Q Nguyen; Vuvi G Tran; Emmanuelle Gras; Yanjie Mao; David H Jung; Christine Tkaczyk; Bret R Sellman; Binh An Diep
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

2.  Neutralizing Staphylococcus aureus Virulence with AZD6389, a Three mAb Combination, Accelerates Closure of a Diabetic Polymicrobial Wound.

Authors:  Christine Tkaczyk; Omari Jones-Nelson; Yue Yue Shi; David E Tabor; Lily Cheng; Tianhui Zhang; Bret R Sellman
Journal:  mSphere       Date:  2022-06-01       Impact factor: 5.029

3.  Mucosa-Associated Invariant T Cell Hypersensitivity to Staphylococcus aureus Leukocidin ED and Its Modulation by Activation.

Authors:  Caroline Boulouis; Edwin Leeansyah; Srikanth Mairpady Shambat; Anna Norrby-Teglund; Johan K Sandberg
Journal:  J Immunol       Date:  2022-02-09       Impact factor: 5.426

4.  Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection.

Authors:  Yanjie Mao; Florent Valour; Nhu T Q Nguyen; Thien M N Doan; Holly Koelkebeck; Christopher Richardson; Lily I Cheng; Bret R Sellman; Christine Tkaczyk; Binh An Diep
Journal:  Antimicrob Agents Chemother       Date:  2021-06-17       Impact factor: 5.191

Review 5.  Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens.

Authors:  Daniel V Zurawski; Molly K McLendon
Journal:  Antibiotics (Basel)       Date:  2020-04-01

Review 6.  Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets.

Authors:  Haijie Hu; Min Liu; Shuang Sun
Journal:  Drug Des Devel Ther       Date:  2021-09-07       Impact factor: 4.162

7.  Bactericidal fully human single-chain fragment variable antibodies protect mice against methicillin-resistant Staphylococcus aureus bacteraemia.

Authors:  Behnoush Soltanmohammadi; Somayeh Piri-Gavgani; Eilnaz Basardeh; Mostafa Ghanei; Masoumeh Azizi; Zabihollah Khaksar; Zahra Sharifzadeh; Farzad Badmasti; Mahdieh Soezi; Abolfazl Fateh; Parisa Azimi; Seyed Davar Siadat; Fahimeh Shooraj; Saeid Bouzari; Mir Davood Omrani; Fatemeh Rahimi-Jamnani
Journal:  Clin Transl Immunology       Date:  2021-06-29
  7 in total

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