Literature DB >> 6601146

The adjuvanticity of interleukin 1 in vivo.

M J Staruch, D D Wood.   

Abstract

Interleukin 1 (IL 1) was shown to enhance in vivo secondary antibody responses of mice to a protein antigen. The activity was found to be dose and time dependent. The maximum enhancing effect was obtained with 2000 LAF units of IL 1 given 2 hr after the priming dose of antigen. The observation is consistent with the in vitro immunoenhancing activities of IL 1 and strongly suggests that this protein may be an important mediator of host defense responses, as well as of the stimulatory effects of some adjuvants.

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Year:  1983        PMID： 6601146

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  27 in total

1.  A limited role of IL-1 in immune-enhancement by adjuvants.

Authors:  T Sagara; S Mori; S Ohkawara; F Goto; K Takagi; M Yoshinaga
Journal:  Immunology       Date:  1990-10       Impact factor: 7.397

2.  Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.

Authors:  William M Gwinn; Shaun M Kirwan; Sheena H Wang; Kathleen A Ashcraft; Neil L Sparks; Catherine R Doil; Tom G Tlusty; Leslie S Casey; Susan K Hollingshead; David E Briles; Richard S Dondero; Anthony J Hickey; W Michael Foster; Herman F Staats
Journal:  Vaccine       Date:  2010-08-17       Impact factor: 3.641

3.  TLR, NLR Agonists, and Other Immune Modulators as Infectious Disease Vaccine Adjuvants.

Authors:  Sarah C Higgins; Kingston H G Mills
Journal:  Curr Infect Dis Rep       Date:  2010-01       Impact factor: 3.725

Review 4.  International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.

Authors:  Clare E Bryant; Selinda Orr; Brian Ferguson; Martyn F Symmons; Joseph P Boyle; Tom P Monie
Journal:  Pharmacol Rev       Date:  2015       Impact factor: 25.468

5.  Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation.

Authors:  J W Mannhalter; H O Neychev; G J Zlabinger; R Ahmad; M M Eibl
Journal:  Clin Exp Immunol       Date:  1985-07       Impact factor: 4.330

6.  The effect of adjuvants and prior immunization on the rate and mode of uptake of antigen into afferent popliteal lymph from sheep.

Authors:  K J Beh; A K Lascelles
Journal:  Immunology       Date:  1985-03       Impact factor: 7.397

7.  Therapeutic use of interleukins: experimental results.

Authors:  R D Granstein; A Tominaga; M I Greene
Journal:  Surv Immunol Res       Date:  1984

8.  Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A.

Authors:  R Glück; R Mischler; S Brantschen; M Just; B Althaus; S J Cryz
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

9.  Molecular cloning and characterization of ovine IL-1 alpha and IL-1 beta.

Authors:  A E Andrews; G J Barcham; M R Brandon; A D Nash
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397

10.  Effects of murine recombinant interleukin 1 on synovial joints in mice: measurement of patellar cartilage metabolism and joint inflammation.

Authors:  A A van de Loo; W B van den Berg
Journal:  Ann Rheum Dis       Date:  1990-04       Impact factor: 19.103
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