Isadora Martini Garcia1, Carolina Jung Ferreira2, Virgínia Serra de Souza3, Vicente Castelo Branco Leitune4, Susana Maria Werner Samuel5, Gabriela de Souza Balbinot6, Amanda de Souza da Motta7, Fernanda Visioli8, Jackson Damiani Scholten9, Fabrício Mezzomo Collares10. 1. Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: isadora.garcia@hotmail.com. 2. Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: carolinajungferreira@yahoo.com.br. 3. Laboratory of Molecular Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, Bento Gonçalves Ave, 9500, Agronomia, Porto Alegre, RS, 91501970, Brazil. Electronic address: vivi_qui@hotmail.com. 4. Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: vicente.leitune@ufrgs.br. 5. Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: susana.samuel@ufrgs.br. 6. Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: gabriela.balbinot@ufrgs.br. 7. Department of Microbiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Sarmento Leite Street, 500, Farroupilha, 90035-190, Brazil. Electronic address: amanda.motta@ufrgs.br. 8. Laboratory of Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: fernanda.visioli@ufrgs.br. 9. Laboratory of Molecular Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, Bento Gonçalves Ave, 9500, Agronomia, Porto Alegre, RS, 91501970, Brazil. Electronic address: jackson.scholten@ufrgs.br. 10. Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: fabricio.collares@ufrgs.br.
Abstract
OBJECTIVE: The aim of this study was to formulate and evaluate experimental orthodontic adhesives with different concentrations of 1-n-butyl-3-methylimidazoilium bis(trifluoromethanesulfonyl)imide (BMIM.NTf2). METHODS: The experimental orthodontic adhesives were formulated with methacrylate monomers, photoinitiators and silica colloidal. The ionic liquid BMIM.NTf2 was synthesized and characterized. BMIM.NTf2 was added at 5 (G5%), 10 (G10%) and 15 (G15%) wt.%. One group contained no BMIM.NTf2 to function as control (GCtrl). The adhesives were evaluated for polymerization kinetics, degree of conversion (DC), Knoop hardness and softening in solvent, ultimate tensile strength (UTS), shear bond strength (SBS), thermogravimetric analysis (TGA), antibacterial activity and cytotoxicity. RESULTS: BMI.NTf2 showed the characteristic chemical peaks. The polymerization kinetics were different among the groups. G10% and G15% showed higher DC (p < 0.05). G5% and GCtrl had no differences for softening in solvent (p > 0.05). There were no differences for UTS (p > 0.05) and SBS (p > 0.05). TGA showed one different peak for G15%. All groups with BMIM.NTf2 showed antibacterial activity compared to GCtrl (p < 0.05) without cytotoxicity (p > 0.05). SIGNIFICANCE: To reduce biofilm formation around brackets and to prevent demineralization at susceptible sites, materials have been developed with antibacterial properties. In this study, a new experimental orthodontic adhesive was formulated with an imidazolium ionic liquid (BMIM.NTf2) as antibacterial agent. The incorporation of 5 wt.% of ionic liquid decreased biofilm formation without affecting the physico-chemical properties and cytotoxicity of an experimental orthodontic resin.
OBJECTIVE: The aim of this study was to formulate and evaluate experimental orthodontic adhesives with different concentrations of 1-n-butyl-3-methylimidazoilium bis(trifluoromethanesulfonyl)imide (BMIM.NTf2). METHODS: The experimental orthodontic adhesives were formulated with methacrylate monomers, photoinitiators and silica colloidal. The ionic liquid BMIM.NTf2 was synthesized and characterized. BMIM.NTf2 was added at 5 (G5%), 10 (G10%) and 15 (G15%) wt.%. One group contained no BMIM.NTf2 to function as control (GCtrl). The adhesives were evaluated for polymerization kinetics, degree of conversion (DC), Knoop hardness and softening in solvent, ultimate tensile strength (UTS), shear bond strength (SBS), thermogravimetric analysis (TGA), antibacterial activity and cytotoxicity. RESULTS: BMI.NTf2 showed the characteristic chemical peaks. The polymerization kinetics were different among the groups. G10% and G15% showed higher DC (p < 0.05). G5% and GCtrl had no differences for softening in solvent (p > 0.05). There were no differences for UTS (p > 0.05) and SBS (p > 0.05). TGA showed one different peak for G15%. All groups with BMIM.NTf2 showed antibacterial activity compared to GCtrl (p < 0.05) without cytotoxicity (p > 0.05). SIGNIFICANCE: To reduce biofilm formation around brackets and to prevent demineralization at susceptible sites, materials have been developed with antibacterial properties. In this study, a new experimental orthodontic adhesive was formulated with an imidazolium ionic liquid (BMIM.NTf2) as antibacterial agent. The incorporation of 5 wt.% of ionic liquid decreased biofilm formation without affecting the physico-chemical properties and cytotoxicity of an experimental orthodontic resin.
Authors: Anatoly N Vereshchagin; Nikita A Frolov; Ksenia S Egorova; Marina M Seitkalieva; Valentine P Ananikov Journal: Int J Mol Sci Date: 2021-06-24 Impact factor: 5.923