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Literature DB >> 31125642

Etiology, cancer stem cells and potential diagnostic biomarkers for esophageal cancer.

Kuancan Liu¹, Tingting Zhao², Junkai Wang³, Yunyun Chen², Rui Zhang⁴, Xiaopeng Lan⁵, Jianwen Que⁶.

Abstract

Esophageal cancer (EC) has been a leading cause of cancer death worldwide in part due to late detection and lack of precision treatment. EC includes two major malignancies, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Recent studies reveal that ESCC and EAC have distinct cell of origin and contain cancer stem cells (also known as tumor initiating cells) expressing different cell surface markers. These biomarkers have potentially important values for both early detection and finding effective therapy. In this review we summarize the updated findings for cell of origin and provide an overview of cancer cell biomarkers that have been tested for ESCC and EAC. In addition, we also discuss recent progress in the study of molecular mechanisms leading to these malignancies.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Barrett's esophagus; Basal cells; Cancer initiation cells; Esophageal adenocarcinoma; Esophageal squamous cell carcinoma

Mesh：

Substances：
Biomarkers, Tumor

Year: 2019 PMID： 31125642 PMCID： PMC6597177 DOI： 10.1016/j.canlet.2019.05.018

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

115 in total

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18 in total

1. Targeting SOX2 Protein with Peptide Aptamers for Therapeutic Gains against Esophageal Squamous Cell Carcinoma.

Authors: Kuancan Liu; Fuan Xie; Tingting Zhao; Rui Zhang; Anding Gao; Yunyun Chen; Haiyan Li; Shihui Zhang; Zhangwu Xiao; Jieping Li; Xiaoqian Hong; Lei Shang; Weifeng Huang; Junkai Wang; Wael El-Rifai; Alexander Zaika; Xi Chen; Jianwen Que; Xiaopeng Lan
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Authors: Gurpal Singh; Harinder Kaur; Akanksha Sharma; Joga Singh; Hema Kumari Alajangi; Santosh Kumar; Neha Singla; Indu Pal Kaur; Ravi Pratap Barnwal
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10. High Content Imaging of Barrett's-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions.

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