PURPOSE AND EXPERIMENTAL DESIGN: To detect surgically resectable tumors earlier and improve the prognosis of esophageal squamous cell carcinoma patients, we examined deltaNp63 expression that was specific for squamous cell carcinoma in blood samples obtained from 43 esophageal cancer patients. RESULTS: Seventeen of 33 (52%) patients with primary esophageal squamous cell carcinoma and 6 of 10 (60%) patients with postoperative recurrent squamous cell carcinoma had detectable deltaNp63 expression in their peripheral blood using deltaNp63-specific reverse transcription-PCR. Furthermore, deltaNp63 is a more sensitive marker compared with other commonly used tumor markers such as squamous cell carcinoma-associated antigen and carcinoembryonic antigen. CONCLUSIONS: This approach would be potentially useful for the monitoring of patients with this aggressive disease.
PURPOSE AND EXPERIMENTAL DESIGN: To detect surgically resectable tumors earlier and improve the prognosis of esophageal squamous cell carcinomapatients, we examined deltaNp63 expression that was specific for squamous cell carcinoma in blood samples obtained from 43 esophageal cancerpatients. RESULTS: Seventeen of 33 (52%) patients with primary esophageal squamous cell carcinoma and 6 of 10 (60%) patients with postoperative recurrent squamous cell carcinoma had detectable deltaNp63 expression in their peripheral blood using deltaNp63-specific reverse transcription-PCR. Furthermore, deltaNp63 is a more sensitive marker compared with other commonly used tumor markers such as squamous cell carcinoma-associated antigen and carcinoembryonic antigen. CONCLUSIONS: This approach would be potentially useful for the monitoring of patients with this aggressive disease.
Authors: Mei Cao; Shang-Mian Yie; Sheng-Min Wu; Shu Chen; Be Lou; Xu He; Shang-Rong Ye; Ke Xie; Lin Rao; En Gao; Nai-Yao Ye Journal: Clin Exp Metastasis Date: 2009-06-12 Impact factor: 5.150
Authors: Xiao-Xin Shi; Jian-Hong An; Ye-En Huang; Yao-Zhong Zhang; Zhuo-Ya Huang; Zhen-Ning Zou; Qing Chen; Hong Shen Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2016-02-20
Authors: Stuart C Winter; Sally-Anne Stephenson; Selva K Subramaniam; Vinidh Paleri; Kien Ha; Conor Marnane; Suren Krishnan; Guy Rees Journal: BMC Cancer Date: 2009-12-06 Impact factor: 4.430