Diana M Toledo1, Patricia A Pioli2. 1. Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, 705 Remsen, Hanover, NH, 03755, USA. 2. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, 644E Borwell Building, Lebanon, NH, 03756, USA. Patricia.A.Pioli@dartmouth.edu.
Abstract
PURPOSE OF REVIEW: Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately to pathology. Activated macrophages have been implicated in the pathogenesis of systemic sclerosis (SSc), although the triggers that induce immune activation in SSc and the signaling pathways that underlie aberrant macrophage activation remain unknown. RECENT FINDINGS: Macrophages are implicated in fibrotic activation in SSc. Targeted therapeutic interventions directed against SSc macrophages may ameliorate inflammation and fibrosis. While current studies have begun to elucidate the role of macrophages in disease initiation and progression, further work is needed to address macrophage subset heterogeneity within and among SSc end-target tissues to determine the disparate functions mediated by these subsets and to identify additional targets for therapeutic intervention.
PURPOSE OF REVIEW: Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately to pathology. Activated macrophages have been implicated in the pathogenesis of systemic sclerosis (SSc), although the triggers that induce immune activation in SSc and the signaling pathways that underlie aberrant macrophage activation remain unknown. RECENT FINDINGS: Macrophages are implicated in fibrotic activation in SSc. Targeted therapeutic interventions directed against SSc macrophages may ameliorate inflammation and fibrosis. While current studies have begun to elucidate the role of macrophages in disease initiation and progression, further work is needed to address macrophage subset heterogeneity within and among SSc end-target tissues to determine the disparate functions mediated by these subsets and to identify additional targets for therapeutic intervention.
Authors: Susan K Mathai; Mridu Gulati; Xueyan Peng; Thomas R Russell; Albert C Shaw; Ami N Rubinowitz; Lynne A Murray; Jonathan M Siner; Danielle E Antin-Ozerkis; Ruth R Montgomery; Ronald A S Reilkoff; Richard J Bucala; Erica L Herzog Journal: Lab Invest Date: 2010-04-19 Impact factor: 5.662
Authors: Natalia Nacu; Irina G Luzina; Kendrick Highsmith; Virginia Lockatell; Kerill Pochetuhen; Zachary A Cooper; Michael P Gillmeister; Nevins W Todd; Sergei P Atamas Journal: J Immunol Date: 2008-04-01 Impact factor: 5.422
Authors: Ausra Milano; Sarah A Pendergrass; Jennifer L Sargent; Lacy K George; Timothy H McCalmont; M Kari Connolly; Michael L Whitfield Journal: PLoS One Date: 2008-07-16 Impact factor: 3.240
Authors: Brian Skaug; Dinesh Khanna; William R Swindell; Monique E Hinchcliff; Tracy M Frech; Virginia D Steen; Faye N Hant; Jessica K Gordon; Ami A Shah; Lisha Zhu; W Jim Zheng; Jeffrey L Browning; Alexander M S Barron; Minghua Wu; Sudha Visvanathan; Patrick Baum; Jennifer M Franks; Michael L Whitfield; Victoria K Shanmugam; Robyn T Domsic; Flavia V Castelino; Elana J Bernstein; Nancy Wareing; Marka A Lyons; Jun Ying; Julio Charles; Maureen D Mayes; Shervin Assassi Journal: Ann Rheum Dis Date: 2019-11-25 Impact factor: 19.103
Authors: Dan Xue; Tracy Tabib; Christina Morse; Yi Yang; Robyn T Domsic; Dinesh Khanna; Robert Lafyatis Journal: Arthritis Rheumatol Date: 2022-01-18 Impact factor: 10.995
Authors: Dan Xu; Swati Bhattacharyya; Wenxia Wang; Igal Ifergan; Ming-Yi Alice Chiang Wong; Daniele Procissi; Anjana Yeldandi; Swarna Bale; Roberta Goncalves Marangoni; Craig Horbinski; Stephen D Miller; John Varga Journal: JCI Insight Date: 2022-03-08