Literature DB >> 15530839

The chemokine system in diverse forms of macrophage activation and polarization.

Alberto Mantovani1, Antonio Sica, Silvano Sozzani, Paola Allavena, Annunciata Vecchi, Massimo Locati.   

Abstract

Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.

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Year:  2004        PMID： 15530839     DOI： 10.1016/j.it.2004.09.015

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  2000 in total

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Review 6.  Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB.

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8.  IL-13Rα1 is a surface marker for M2 macrophages influencing their differentiation and function.

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Review 9.  Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.

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