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Literature DB >> 3110848

Effects of amphetamine on local cerebral metabolism in normal and schizophrenic subjects as determined by positron emission tomography.

A Wolkin, B Angrist, A Wolf, J Brodie, B Wolkin, J Jaeger, R Cancro, J Rotrosen.

Abstract

The effects of d-amphetamine (0.5 mg/kg PO) on regional cerebral glucose utilization were measured with Positron Emission Tomography (PET). Subjects included ten chronic schizophrenics and six controls who received amphetamine, and six chronic schizophrenics and nine controls who received placebo or no treatment. Amphetamine decreased glucose metabolism in all regions studied (frontal, temporal, and striatal) in normal and schizophrenic subjects. The metabolic effects of amphetamine were correlated with plasma level of the drug. Cortical atrophy was associated with a blunted metabolic response.

Entities: Chemical Disease

Mesh：

Substances：
Amphetamine

Year: 1987 PMID： 3110848 DOI： 10.1007/bf00177923

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

36 in total

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14 in total

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2. Effects of amisulpride on human resting cerebral perfusion.

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Journal: Psychopharmacology (Berl) Date: 2013-04-13 Impact factor: 4.530

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Authors: Stephen V Faraone
Journal: Neurosci Biobehav Rev Date: 2018-02-08 Impact factor: 8.989

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Journal: Psychopharmacology (Berl) Date: 1996-01 Impact factor: 4.530

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Authors: Ursula F Bailer; Rajesh Narendran; W Gordon Frankle; Michael L Himes; Vikas Duvvuri; Chester A Mathis; Walter H Kaye
Journal: Int J Eat Disord Date: 2011-05-03 Impact factor: 4.861

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Journal: Psychopharmacology (Berl) Date: 2005-09-14 Impact factor: 4.530

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Journal: Hum Brain Mapp Date: 2007-07 Impact factor: 5.038