Literature DB >> 31097655

Senolytic therapies for healthy longevity.

Jan M van Deursen1.   

Abstract

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Year:  2019        PMID： 31097655      PMCID： PMC6816502          DOI： 10.1126/science.aaw1299

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


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  12 in total

Review 1.  The role of senescent cells in ageing.

Authors:  Jan M van Deursen
Journal:  Nature       Date:  2014-05-22       Impact factor: 49.962

2.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Authors:  Darren J Baker; Tobias Wijshake; Tamar Tchkonia; Nathan K LeBrasseur; Bennett G Childs; Bart van de Sluis; James L Kirkland; Jan M van Deursen
Journal:  Nature       Date:  2011-11-02       Impact factor: 49.962

3.  Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Authors:  Bennett G Childs; Darren J Baker; Tobias Wijshake; Cheryl A Conover; Judith Campisi; Jan M van Deursen
Journal:  Science       Date:  2016-10-27       Impact factor: 47.728

4.  Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Authors:  Ok Hee Jeon; Chaekyu Kim; Remi-Martin Laberge; Marco Demaria; Sona Rathod; Alain P Vasserot; Jae Wook Chung; Do Hun Kim; Yan Poon; Nathaniel David; Darren J Baker; Jan M van Deursen; Judith Campisi; Jennifer H Elisseeff
Journal:  Nat Med       Date:  2017-04-24       Impact factor: 53.440

5.  Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

Authors:  Jianhui Chang; Yingying Wang; Lijian Shao; Remi-Martin Laberge; Marco Demaria; Judith Campisi; Krishnamurthy Janakiraman; Norman E Sharpless; Sheng Ding; Wei Feng; Yi Luo; Xiaoyan Wang; Nukhet Aykin-Burns; Kimberly Krager; Usha Ponnappan; Martin Hauer-Jensen; Aimin Meng; Daohong Zhou
Journal:  Nat Med       Date:  2015-12-14       Impact factor: 53.440

6.  Programmed cell senescence during mammalian embryonic development.

Authors:  Daniel Muñoz-Espín; Marta Cañamero; Antonio Maraver; Gonzalo Gómez-López; Julio Contreras; Silvia Murillo-Cuesta; Alfonso Rodríguez-Baeza; Isabel Varela-Nieto; Jesús Ruberte; Manuel Collado; Manuel Serrano
Journal:  Cell       Date:  2013-11-14       Impact factor: 41.582

7.  Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Authors:  Jean-Philippe Coppé; Christopher K Patil; Francis Rodier; Yu Sun; Denise P Muñoz; Joshua Goldstein; Peter S Nelson; Pierre-Yves Desprez; Judith Campisi
Journal:  PLoS Biol       Date:  2008-12-02       Impact factor: 8.029

8.  Senolytics improve physical function and increase lifespan in old age.

Authors:  Ming Xu; Tamar Pirtskhalava; Joshua N Farr; Bettina M Weigand; Allyson K Palmer; Megan M Weivoda; Christina L Inman; Mikolaj B Ogrodnik; Christine M Hachfeld; Daniel G Fraser; Jennifer L Onken; Kurt O Johnson; Grace C Verzosa; Larissa G P Langhi; Moritz Weigl; Nino Giorgadze; Nathan K LeBrasseur; Jordan D Miller; Diana Jurk; Ravinder J Singh; David B Allison; Keisuke Ejima; Gene B Hubbard; Yuji Ikeno; Hajrunisa Cubro; Vesna D Garovic; Xiaonan Hou; S John Weroha; Paul D Robbins; Laura J Niedernhofer; Sundeep Khosla; Tamara Tchkonia; James L Kirkland
Journal:  Nat Med       Date:  2018-07-09       Impact factor: 53.440

9.  Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Authors:  Darren J Baker; Bennett G Childs; Matej Durik; Melinde E Wijers; Cynthia J Sieben; Jian Zhong; Rachel A Saltness; Karthik B Jeganathan; Grace Casaclang Verzosa; Abdulmohammad Pezeshki; Khashayarsha Khazaie; Jordan D Miller; Jan M van Deursen
Journal:  Nature       Date:  2016-02-03       Impact factor: 49.962

10.  Fisetin is a senotherapeutic that extends health and lifespan.

Authors:  Matthew J Yousefzadeh; Yi Zhu; Sara J McGowan; Luise Angelini; Heike Fuhrmann-Stroissnigg; Ming Xu; Yuan Yuan Ling; Kendra I Melos; Tamar Pirtskhalava; Christina L Inman; Collin McGuckian; Erin A Wade; Jonathon I Kato; Diego Grassi; Mark Wentworth; Christin E Burd; Edgar A Arriaga; Warren L Ladiges; Tamara Tchkonia; James L Kirkland; Paul D Robbins; Laura J Niedernhofer
Journal:  EBioMedicine       Date:  2018-09-29       Impact factor: 8.143
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  58 in total

1.  Senolytics: targeting senescent cells for age-associated diseases.

Authors:  Iman M A Al-Naggar; George A Kuchel; Ming Xu
Journal:  Curr Mol Biol Rep       Date:  2020-10-24

Review 2.  New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease.

Authors:  Xinghui Sun; Edward N Harris
Journal:  Am J Physiol Cell Physiol       Date:  2020-05-06       Impact factor: 4.249

3.  NIA workshop on senescence in brain aging and Alzheimer's disease and its related dementias.

Authors:  Amanda M DiBattista; Felipe Sierra; Eliezer Masliah
Journal:  Geroscience       Date:  2020-01-13       Impact factor: 7.713

Review 4.  The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis.

Authors:  Maria Eugenia Guicciardi; Christy E Trussoni; Nicholas F LaRusso; Gregory J Gores
Journal:  Hepatology       Date:  2020-02       Impact factor: 17.425

5.  Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.

Authors:  Mareike Lehmann; Qianjiang Hu; Yan Hu; Kathrin Hafner; Rita Costa; Anastasia van den Berg; Melanie Königshoff
Journal:  Cell Signal       Date:  2020-02-26       Impact factor: 4.315

Review 6.  Cellular senescence as a possible link between prostate diseases of the ageing male.

Authors:  Gaelle Fiard; Vasilis Stavrinides; Emma S Chambers; Susan Heavey; Alex Freeman; Rhys Ball; Arne N Akbar; Mark Emberton
Journal:  Nat Rev Urol       Date:  2021-07-22       Impact factor: 14.432

Review 7.  Regenerative medicine clinical readiness.

Authors:  Satsuki Yamada; Atta Behfar; Andre Terzic
Journal:  Regen Med       Date:  2021-02-24       Impact factor: 3.806

8.  National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials.

Authors:  Sergei Romashkan; Henry Chang; Evan C Hadley
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2021-05-22       Impact factor: 6.053

9.  The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence.

Authors:  M E Copp; M C Flanders; R Gagliardi; J M Gilbertie; G A Sessions; S Chubinskaya; R F Loeser; L V Schnabel; B O Diekman
Journal:  Osteoarthritis Cartilage       Date:  2020-11-20       Impact factor: 6.576

Review 10.  Small-molecule drug repurposing to target DNA damage repair and response pathways.

Authors:  Jacqueline A Brinkman; Yue Liu; Stephen J Kron
Journal:  Semin Cancer Biol       Date:  2020-02-27       Impact factor: 15.707
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