Literature DB >> 33777657

Senolytics: targeting senescent cells for age-associated diseases.

Iman M A Al-Naggar1, George A Kuchel1, Ming Xu1,2.   

Abstract

Keywords:  Aging; Cellular senescence; Healthspan; Lifespan; Senolytics

Year:  2020        PMID： 33777657      PMCID： PMC7992369          DOI： 10.1007/s40610-020-00140-1

Source DB:  PubMed          Journal:  Curr Mol Biol Rep        ISSN： 2198-6428


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  83 in total

1.  p53 has a direct apoptogenic role at the mitochondria.

Authors:  Motohiro Mihara; Susan Erster; Alexander Zaika; Oleksi Petrenko; Thomas Chittenden; Petr Pancoska; Ute M Moll
Journal:  Mol Cell       Date:  2003-03       Impact factor: 17.970

2.  Hsp90 inhibitors as senolytic drugs to extend healthy aging.

Authors:  Heike Fuhrmann-Stroissnigg; Laura J Niedernhofer; Paul D Robbins
Journal:  Cell Cycle       Date:  2018-07-23       Impact factor: 4.534

Review 3.  Reviewing the future of the P53 field.

Authors:  Arnold J Levine
Journal:  Cell Death Differ       Date:  2018-01       Impact factor: 15.828

4.  Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Authors:  Ok Hee Jeon; Chaekyu Kim; Remi-Martin Laberge; Marco Demaria; Sona Rathod; Alain P Vasserot; Jae Wook Chung; Do Hun Kim; Yan Poon; Nathaniel David; Darren J Baker; Jan M van Deursen; Judith Campisi; Jennifer H Elisseeff
Journal:  Nat Med       Date:  2017-04-24       Impact factor: 53.440

5.  Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.

Authors:  Alireza Farsad-Naeimi; Mohammad Alizadeh; Ali Esfahani; Esmaeil Darvish Aminabad
Journal:  Food Funct       Date:  2018-04-25       Impact factor: 5.396

6.  Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

Authors:  Uxía Nogueira-Recalde; Irene Lorenzo-Gómez; Francisco J Blanco; María I Loza; Diego Grassi; Valery Shirinsky; Ivan Shirinsky; Martin Lotz; Paul D Robbins; Eduardo Domínguez; Beatriz Caramés
Journal:  EBioMedicine       Date:  2019-07-05       Impact factor: 8.143

7.  Identification and characterization of Cardiac Glycosides as senolytic compounds.

Authors:  Francisco Triana-Martínez; Pilar Picallos-Rabina; Sabela Da Silva-Álvarez; Federico Pietrocola; Susana Llanos; Verónica Rodilla; Enrica Soprano; Pablo Pedrosa; Alba Ferreirós; Marta Barradas; Fernanda Hernández-González; Marta Lalinde; Neus Prats; Cristina Bernadó; Patricia González; María Gómez; Maria P Ikonomopoulou; Pablo J Fernández-Marcos; Tomás García-Caballero; Pablo Del Pino; Joaquín Arribas; Anxo Vidal; Miguel González-Barcia; Manuel Serrano; María I Loza; Eduardo Domínguez; Manuel Collado
Journal:  Nat Commun       Date:  2019-10-21       Impact factor: 14.919

Review 8.  Discovery, development, and future application of senolytics: theories and predictions.

Authors:  Erin O Wissler Gerdes; Yi Zhu; Tamar Tchkonia; James L Kirkland
Journal:  FEBS J       Date:  2020-03-17       Impact factor: 5.542

9.  Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

Authors:  LaTonya J Hickson; Larissa G P Langhi Prata; Shane A Bobart; Tamara K Evans; Nino Giorgadze; Shahrukh K Hashmi; Sandra M Herrmann; Michael D Jensen; Qingyi Jia; Kyra L Jordan; Todd A Kellogg; Sundeep Khosla; Daniel M Koerber; Anthony B Lagnado; Donna K Lawson; Nathan K LeBrasseur; Lilach O Lerman; Kathleen M McDonald; Travis J McKenzie; João F Passos; Robert J Pignolo; Tamar Pirtskhalava; Ishran M Saadiq; Kalli K Schaefer; Stephen C Textor; Stella G Victorelli; Tammie L Volkman; Ailing Xue; Mark A Wentworth; Erin O Wissler Gerdes; Yi Zhu; Tamara Tchkonia; James L Kirkland
Journal:  EBioMedicine       Date:  2019-09-18       Impact factor: 8.143

10.  Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.

Authors:  Yonghan He; Wen Li; Dongwen Lv; Xin Zhang; Xuan Zhang; Yuma T Ortiz; Vivekananda Budamagunta; Judith Campisi; Guangrong Zheng; Daohong Zhou
Journal:  Aging Cell       Date:  2020-02-16       Impact factor: 9.304
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