Literature DB >> 3109392

Effect of alpha-difluoromethylornithine on DNA methylation in murine erythroleukaemic cells. Relationship to stimulation of induced differentiation.

P Papazafiri, H B Osborne.   

Abstract

Murine erythroleukaemic (MEL) cells cultured with alpha-difluoromethylornithine (DFMO) accumulated decarboxylated S-adenosylmethionine(decarboxylated AdoMet). In the absence of the inducer hexamethylenebisacetamide (HMBA), this accumulation of decarboxylated AdoMet was associated with a concomitant and proportional increase in DNA hypomethylation. In the presence of HMBA, DFMO, which stimulates the erythrodifferentiation of MEL cells, enhanced the differentiation-associated DNA hypomethylation. However, this differentiation-associated DNA hypomethylation was neither temporally nor quantitatively correlated with the accumulation of decarboxylated AdoMet in these cells. Therefore DFMO probably stimulates the HMBA-induced differentiation of MEL cells and the associated DNA hypomethylation via the effect of this drug on polyamine biosynthesis.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3109392      PMCID： PMC1147730          DOI： 10.1042/bj2420479

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  Differentiation of two mouse cell lines is associated with hypomethylation of their genomes.

Authors:  T H Bestor; S B Hellewell; V M Ingram
Journal:  Mol Cell Biol       Date:  1984-09       Impact factor: 4.272

2.  Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

Authors:  T H Bestor; V M Ingram
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

3.  Catabolites produced by the deacetylation of hexamethylenebisacetamide play a key role in murine erythroleukaemic-cell differentiation.

Authors:  E Meilhoc; M J Moutin; H B Osborne
Journal:  Biochem J       Date:  1986-09-15       Impact factor: 3.857

Review 4.  Polyamine metabolism and function.

Authors:  A E Pegg; P P McCann
Journal:  Am J Physiol       Date:  1982-11

5.  High-performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivatives.

Authors:  N Seiler; B Knödgen
Journal:  J Chromatogr       Date:  1980-12-12

6.  Reversed-phase ion-pair liquid chromatographic procedure for the simultaneous analysis of S-adenosylmethionine, its metabolites and the natural polyamines.

Authors:  J Wagner; C Danzin; P Mamont
Journal:  J Chromatogr       Date:  1982-02-12

7.  Effect of inhibition of polyamine synthesis on the content of decarboxylated S-adenosylmethionine.

Authors:  A E Pegg; H Pösö; K Shuttleworth; R A Bennett
Journal:  Biochem J       Date:  1982-02-15       Impact factor: 3.857

8.  Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis.

Authors:  P S Mamont; C Danzin; J Wagner; M Siat; A M Joder-Ohlenbusch; N Claverie
Journal:  Eur J Biochem       Date:  1982-04

9.  Stimulation of melanotic expression in murine melanoma cells exposed to polyamine antimetabolites.

Authors:  K Käpyaho; J Jänne
Journal:  Biochem Biophys Res Commun       Date:  1983-05-31       Impact factor: 3.575

10.  Effects of inhibitors of ornithine decarboxylase on the differentiation of mouse neuroblastoma cells.

Authors:  K Y Chen; D Nau; A Y Liu
Journal:  Cancer Res       Date:  1983-06       Impact factor: 12.701
View more
  6 in total

1.  Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools?

Authors:  Robert A Casero
Journal:  Cancer Discov       Date:  2013-09       Impact factor: 39.397

2.  Spermine induces haemoglobin synthesis in murine erythroleukaemia cells.

Authors:  J G Delcros; B Schwartz; S Clément; H S Basu; L J Marton; B G Feuerstein
Journal:  Biochem J       Date:  1995-08-01       Impact factor: 3.857

Review 3.  Overview of Polyamines as Nutrients for Human Healthy Long Life and Effect of Increased Polyamine Intake on DNA Methylation.

Authors:  Kuniyasu Soda
Journal:  Cells       Date:  2022-01-04       Impact factor: 6.600

4.  Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis.

Authors:  Kuniyasu Soda; Yoshihiko Kano; Fumihiro Chiba; Kei Koizumi; Yuichiro Miyaki
Journal:  PLoS One       Date:  2013-05-16       Impact factor: 3.240

Review 5.  Chemical inducers of differentiation in a long-term renal cell line.

Authors:  J E Lever
Journal:  Environ Health Perspect       Date:  1989-03       Impact factor: 9.031

Review 6.  Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism.

Authors:  Kuniyasu Soda
Journal:  Int J Mol Sci       Date:  2018-10-10       Impact factor: 5.923
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.