Literature DB >> 24019331

Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools?

Robert A Casero1.   

Abstract

In this issue of Cancer Discovery, Witherspoon and colleagues use an unbiased metabolite profiling approach to study the effects of polyamine depletion by 2-difluoromethylornithine in colon cancer cells. Their surprising findings indicate that it is a decrease in thymidine pools resulting from altered tetrahydrofolate availability rather than decreases in polyamines that produces cytostasis. ©2013 AACR.

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Year:  2013        PMID： 24019331      PMCID： PMC3786367          DOI： 10.1158/2159-8290.CD-13-0427

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  15 in total

1.  Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.

Authors:  Patricia A Thompson; Betsy C Wertheim; Jason A Zell; Wen-Pin Chen; Christine E McLaren; Bonnie J LaFleur; Frank L Meyskens; Eugene W Gerner
Journal:  Gastroenterology       Date:  2010-06-09       Impact factor: 22.682

2.  Difluoromethylornithine: the proof is in the polyamines.

Authors:  Joanne M Jeter; David S Alberts
Journal:  Cancer Prev Res (Phila)       Date:  2012-12

3.  Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line.

Authors:  Daisuke Yamamoto; Kaori Shima; Kou Matsuo; Takashi Nishioka; Chang Yan Chen; Guo-Fu Hu; Akira Sasaki; Takanori Tsuji
Journal:  PLoS One       Date:  2010-09-03       Impact factor: 3.240

4.  Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.

Authors:  Mavee Witherspoon; Qiuying Chen; Levy Kopelovich; Steven S Gross; Steven M Lipkin
Journal:  Cancer Discov       Date:  2013-06-14       Impact factor: 39.397

Review 5.  Antizyme and antizyme inhibitor, a regulatory tango.

Authors:  Chaim Kahana
Journal:  Cell Mol Life Sci       Date:  2009-04-28       Impact factor: 9.261

Review 6.  Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.

Authors:  Robert A Casero; Laurence J Marton
Journal:  Nat Rev Drug Discov       Date:  2007-05       Impact factor: 84.694

7.  Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial.

Authors:  Frank L Meyskens; Christine E McLaren; Daniel Pelot; Sharon Fujikawa-Brooks; Philip M Carpenter; Ernest Hawk; Gary Kelloff; Michael J Lawson; Jayashri Kidao; John McCracken; C Gregory Albers; Dennis J Ahnen; D Kim Turgeon; Steven Goldschmid; Peter Lance; Curt H Hagedorn; Daniel L Gillen; Eugene W Gerner
Journal:  Cancer Prev Res (Phila)       Date:  2008-06

8.  Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools.

Authors:  G Bistulfi; P Diegelman; B A Foster; D L Kramer; C W Porter; D J Smiraglia
Journal:  FASEB J       Date:  2009-05-05       Impact factor: 5.191

9.  Effect of DL-alpha-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei.

Authors:  N Yarlett; C J Bacchi
Journal:  Mol Biochem Parasitol       Date:  1988-01-01       Impact factor: 1.759

10.  Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series.

Authors:  Francesco Checchi; Patrice Piola; Harriet Ayikoru; Florence Thomas; Dominique Legros; Gerardo Priotto
Journal:  PLoS Negl Trop Dis       Date:  2007-11-07
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  3 in total

Review 1.  At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer.

Authors:  Dana M Hardbower; Richard M Peek; Keith T Wilson
Journal:  J Leukoc Biol       Date:  2014-05-27       Impact factor: 4.962

2.  Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.

Authors:  Hayley C Affronti; Mark D Long; Spencer R Rosario; Bryan M Gillard; Ellen Karasik; Christoph S Boerlin; Anthony J Pellerite; Barbara A Foster; Kristopher Attwood; Roberto Pili; John H Wilton; Moray J Campbell; Dominic J Smiraglia
Journal:  Oncotarget       Date:  2017-10-20

Review 3.  Role of Polyamines in Immune Cell Functions.

Authors:  Rebecca S Hesterberg; John L Cleveland; Pearlie K Epling-Burnette
Journal:  Med Sci (Basel)       Date:  2018-03-08
  3 in total

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