| Literature DB >> 31086327 |
Rebecca C Coll1, James R Hill2, Christopher J Day3, Alina Zamoshnikova2,4, Dave Boucher2,5, Nicholas L Massey2, Jessica L Chitty6,7,8, James A Fraser6, Michael P Jennings3, Avril A B Robertson9,10, Kate Schroder11,12.
Abstract
Inhibition of the NLRP3 inflammasome is a promising strategy for the development of new treatments for inflammatory diseases. MCC950 is a potent and specific small-molecule inhibitor of the NLRP3 pathway, but its molecular target is not defined. Here, we show that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibiting NLRP3 activation and inflammasome formation.Entities:
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Year: 2019 PMID： 31086327 DOI： 10.1038/s41589-019-0277-7
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040