Literature DB >> 32236886

Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases.

Danbin Wu1, Yefei Chen1, Yingxin Sun1, Qing Gao1, Bin Yu1, Xijuan Jiang2, Maojuan Guo3.   

Abstract

This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation-driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases.

Entities:  

Keywords:  Apoptosis; Cancer; Gasdermin family; Inflammation-driven disease; Pyroptosis

Year:  2020        PMID： 32236886      PMCID： PMC7511492          DOI： 10.1007/s12079-020-00564-5

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  69 in total

1.  Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.

Authors:  Kinlin L Chao; Liudmila Kulakova; Osnat Herzberg
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-01       Impact factor: 11.205

2.  Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland.

Authors:  Declan P Lunny; Erica Weed; Patrick M Nolan; Andreas Marquardt; Martin Augustin; Rebecca M Porter
Journal:  J Invest Dermatol       Date:  2005-03       Impact factor: 8.551

3.  GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.

Authors:  Qin Chen; Peiliang Shi; Yufang Wang; Dayuan Zou; Xiuwen Wu; Dingyu Wang; Qiongyuan Hu; Yujie Zou; Zan Huang; Jianan Ren; Zhaoyu Lin; Xiang Gao
Journal:  J Mol Cell Biol       Date:  2019-06-01       Impact factor: 6.216

4.  Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells.

Authors:  N Saeki; Y Kuwahara; H Sasaki; H Satoh; T Shiroishi
Journal:  Mamm Genome       Date:  2000-09       Impact factor: 2.957

5.  Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Authors:  Kaiwen W Chen; Benjamin Demarco; Rosalie Heilig; Kateryna Shkarina; Andreas Boettcher; Christopher J Farady; Pawel Pelczar; Petr Broz
Journal:  EMBO J       Date:  2019-03-22       Impact factor: 11.598

6.  Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

Authors:  Yupeng Wang; Wenqing Gao; Xuyan Shi; Jingjin Ding; Wang Liu; Huabin He; Kun Wang; Feng Shao
Journal:  Nature       Date:  2017-05-01       Impact factor: 49.962

7.  Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.

Authors:  Gabriel Sollberger; Axel Choidas; Garth Lawrence Burn; Peter Habenberger; Raffaella Di Lucrezia; Susanne Kordes; Sascha Menninger; Jan Eickhoff; Peter Nussbaumer; Bert Klebl; Renate Krüger; Alf Herzig; Arturo Zychlinsky
Journal:  Sci Immunol       Date:  2018-08-24

8.  A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.

Authors:  Ronald A Panganiban; Maoyun Sun; Amber Dahlin; Hae-Ryung Park; Mengyuan Kan; Blanca E Himes; Jennifer A Mitchel; Carlos Iribarren; Eric Jorgenson; Scott H Randell; Elliot Israel; Kelan Tantisira; Stephanie Shore; Jin-Ah Park; Scott T Weiss; Ann Chen Wu; Quan Lu
Journal:  J Allergy Clin Immunol       Date:  2018-01-09       Impact factor: 10.793

9.  Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.

Authors:  Xing Liu; Zhibin Zhang; Jianbin Ruan; Youdong Pan; Venkat Giri Magupalli; Hao Wu; Judy Lieberman
Journal:  Nature       Date:  2016-07-07       Impact factor: 49.962

10.  N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting.

Authors:  Pei-Hsuan Lin; Hsien-Yi Lin; Cheng-Chin Kuo; Liang-Tung Yang
Journal:  J Biomed Sci       Date:  2015-06-24       Impact factor: 8.410
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  8 in total

1.  NLRP3 inflammasome as a novel therapeutic target for heart failure.

Authors:  Shuangcui Wang; Jiaqi Zhang; Yuli Wang; Xijuan Jiang; Maojuan Guo; Zhen Yang
Journal:  Anatol J Cardiol       Date:  2022-01       Impact factor: 1.596

Review 2.  Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma.

Authors:  Yandong Miao; Yonggang Chen; Denghai Mi
Journal:  Heliyon       Date:  2022-10-10

3.  Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice.

Authors:  Pauline Puylaert; Melissa Van Praet; Frederik Vaes; Cédric H G Neutel; Lynn Roth; Pieter-Jan Guns; Guido R Y De Meyer; Wim Martinet
Journal:  Biomedicines       Date:  2022-05-19

Review 4.  Induction of Pyroptosis: A Promising Strategy for Cancer Treatment.

Authors:  Lei Wang; Xiaowei Qin; Jianmin Liang; Pengfei Ge
Journal:  Front Oncol       Date:  2021-02-26       Impact factor: 6.244

5.  A comprehensive analysis of gasdermin family gene as therapeutic targets in pan-cancer.

Authors:  Cheng-Long Huo; Yan Deng; Zhen-Gang Sun
Journal:  Sci Rep       Date:  2022-08-03       Impact factor: 4.996

Review 6.  The role of pyroptosis and its crosstalk with immune therapy in breast cancer.

Authors:  Ling Wu; Hongsheng Lu; Yin Pan; Chen Liu; Jinyan Wang; Baofu Chen; Yichao Wang
Journal:  Front Immunol       Date:  2022-08-30       Impact factor: 8.786

7.  The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages.

Authors:  Wenyun Zeng; Danbin Wu; Yingxin Sun; Yanrong Suo; Qun Yu; Miao Zeng; Qing Gao; Bin Yu; Xijuan Jiang; Yijing Wang
Journal:  Sci Rep       Date:  2021-09-29       Impact factor: 4.379

Review 8.  Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment.

Authors:  Sheng-Kai Hsu; Chia-Yang Li; I-Ling Lin; Wun-Jyun Syue; Yih-Fung Chen; Kai-Chun Cheng; Yen-Ni Teng; Yi-Hsiung Lin; Chia-Hung Yen; Chien-Chih Chiu
Journal:  Theranostics       Date:  2021-08-12       Impact factor: 11.556
  8 in total

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