Literature DB >> 3108449

Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer.

W M Yokoyama, F Koning, G Stingl, J A Bluestone, J E Coligan, E M Shevach.   

Abstract

We have produced a T cell hybridoma line by fusion of an IL-2-dependent, long-term T cell receptor (TCR) gamma/delta+ Thy-1+, bone marrow-derived, dendritic epidermal cell line to the BW5147 tumor line. The resultant hybridoma was rapidly growing, lymphokine independent, and expressed T3 in association with the TCR gamma/delta heterodimer. Several subclones of the hybridoma line produced easily detectable levels of IL-2 after stimulation by anti-T3 or Con A. The availability of these cloned cell lines should greatly facilitate further functional, biochemical, and molecular studies of the TCR delta chain.

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Year:  1987        PMID： 3108449      PMCID： PMC2188374          DOI： 10.1084/jem.165.6.1725

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

Review 1.  The antigen-specific, major histocompatibility complex-restricted receptor on T cells.

Authors:  P Marrack; J Kappler
Journal:  Adv Immunol       Date:  1986       Impact factor: 3.543

2.  A unique T-cell receptor complex expressed on human fetal lymphocytes displaying natural-killer-like activity.

Authors:  P Moingeon; A Ythier; G Goubin; F Faure; A Nowill; L Delmon; M Rainaud; F Forestier; F Daffos; C Bohuon
Journal:  Nature       Date:  1986 Oct 16-22       Impact factor: 49.962

3.  Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer.

Authors:  A Weiss; M Newton; D Crommie
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

4.  Characterization of an anti-peptide antibody that recognizes the murine analogue of the human T cell antigen receptor-T3 delta-chain.

Authors:  L E Samelson; A M Weissman; F A Robey; I Berkower; R D Klausner
Journal:  J Immunol       Date:  1986-11-15       Impact factor: 5.422

5.  A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.

Authors:  I Bank; R A DePinho; M B Brenner; J Cassimeris; F W Alt; L Chess
Journal:  Nature       Date:  1986 Jul 10-16       Impact factor: 49.962

6.  Identification of a putative second T-cell receptor.

Authors:  M B Brenner; J McLean; D P Dialynas; J L Strominger; J A Smith; F L Owen; J G Seidman; S Ip; F Rosen; M S Krangel
Journal:  Nature       Date:  1986 Jul 10-16       Impact factor: 49.962

7.  Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes.

Authors:  A M Lew; D M Pardoll; W L Maloy; B J Fowlkes; A Kruisbeek; S F Cheng; R N Germain; J A Bluestone; R H Schwartz; J E Coligan
Journal:  Science       Date:  1986-12-12       Impact factor: 47.728

8.  Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

Authors:  J Kappler; J White; D Wegmann; E Mustain; P Marrack
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

9.  Expression of the human T cell receptor as defined by anti-isotypic antibodies.

Authors:  A M Lew; W L Maloy; F Koning; R Valas; J E Coligan
Journal:  J Immunol       Date:  1987-02-01       Impact factor: 5.422

10.  Production of autoreactive I region-restricted T cell hybridomas.

Authors:  L H Glimcher; E M Shevach
Journal:  J Exp Med       Date:  1982-08-01       Impact factor: 14.307
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  7 in total

1.  Gamma delta antigen receptors of Thy-1+ dendritic epidermal cells: implications for thymic differentiation.

Authors:  J P Allison; W L Havran; D Asarnow; R E Tigelaar; P W Tucker; M Bonyhadi
Journal:  Immunol Res       Date:  1988       Impact factor: 2.829

2.  Expression of the alpha/beta and gamma/delta T-cell receptors in 57 cases of peripheral T-cell lymphomas. Identification of a subset of gamma/delta T-cell lymphomas.

Authors:  P Gaulard; P Bourquelot; P Kanavaros; C Haioun; J P Le Couedic; M Divine; M Goossens; E S Zafrani; J P Farcet; F Reyes
Journal:  Am J Pathol       Date:  1990-09       Impact factor: 4.307

3.  Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody.

Authors:  W L Havran; S Grell; G Duwe; J Kimura; A Wilson; A M Kruisbeek; R L O'Brien; W Born; R E Tigelaar; J P Allison
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

4.  The mouse vitronectin receptor is a T cell activation antigen.

Authors:  K Moulder; K Roberts; E M Shevach; J E Coligan
Journal:  J Exp Med       Date:  1991-02-01       Impact factor: 14.307

5.  T cell receptor gamma/delta chain diversity.

Authors:  F Koning; A M Kruisbeek; W L Maloy; S Marusic-Galesic; D M Pardoll; E M Shevach; G Stingl; R Valas; W M Yokoyama; J E Coligan
Journal:  J Exp Med       Date:  1988-02-01       Impact factor: 14.307

6.  The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells.

Authors:  K Roberts; W M Yokoyama; P J Kehn; E M Shevach
Journal:  J Exp Med       Date:  1991-01-01       Impact factor: 14.307

7.  Murine T cells express a cell surface receptor for multiple extracellular matrix proteins. Identification and characterization with monoclonal antibodies.

Authors:  S R Maxfield; K Moulder; F Koning; A Elbe; G Stingl; J E Coligan; E M Shevach; W M Yokoyama
Journal:  J Exp Med       Date:  1989-06-01       Impact factor: 14.307
  7 in total

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