Literature DB >> 6980413

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

J Kappler, J White, D Wegmann, E Mustain, P Marrack.   

Abstract

The Ia+, H-2d BALB/c lymphoma cell line L10.A 2J was fused to T cell-depleted spleen cells from mouse strains bearing other H-2 haplotypes. A portion of the selected hybrids expressed Ia antigens of the normal spleen cell partner in the fusion as evidenced by their presentation of various antigens to a set of antigen-specific I-region-restricted T cell hybridomas. Three cloned hybrids were studied in detail. Antigen presentation was shown to be inhibited specifically by monoclonal anti-Ia antibodies. Both I-A and I-E molecules were expressed, including in the one case examined hybrid I-A and I-E molecules between the H-2d and H-2b haplotypes. These Ia+ B cell hybridomas provide a useful set of tools for studying the role of I-region-encoded molecules in antigen presentation to T cells.

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Year:  1982        PMID： 6980413      PMCID： PMC346471          DOI： 10.1073/pnas.79.11.3604

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

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Journal:  Cell Immunol       Date:  1975-07       Impact factor: 4.868

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Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

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Authors:  B Sredni; H Y Tse; R H Schwartz
Journal:  Nature       Date:  1980-02-07       Impact factor: 49.962

4.  Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

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Journal:  Curr Top Microbiol Immunol       Date:  1978       Impact factor: 4.291

5.  Establishment and characterization of BALB/c lymphoma lines with B cell properties.

Authors:  K J Kim; C Kanellopoulos-Langevin; R M Merwin; D H Sachs; R Asofsky
Journal:  J Immunol       Date:  1979-02       Impact factor: 5.422

6.  Macrophage Ia antigens. I. macrophage populations differ in their expression of Ia antigens.

Authors:  C Cowing; B D Schwartz; H B Dickler
Journal:  J Immunol       Date:  1978-02       Impact factor: 5.422

7.  Clonal induction of helper T cells: conversion of specific signals into nonspecific signals.

Authors:  M H Schreier; R Tees
Journal:  Int Arch Allergy Appl Immunol       Date:  1980

8.  Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

Authors:  J Watson
Journal:  J Exp Med       Date:  1979-12-01       Impact factor: 14.307

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Authors:  R I Mishell; R W Dutton
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307

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Authors:  R M Steinman; G Kaplan; M D Witmer; Z A Cohn
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307
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  87 in total

1.  Alternate interactions define the binding of peptides to the MHC molecule IA(b).

Authors:  Xinqi Liu; Shaodong Dai; Frances Crawford; Rachel Fruge; Philippa Marrack; John Kappler
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-25       Impact factor: 11.205

2.  Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.

Authors:  C E Malstrom; A L Kotsenas; B Jones
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

3.  Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

Authors:  K L Rock; L Rothstein; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

4.  Expression of the CD4 gene requires a Myb transcription factor.

Authors:  G Siu; A L Wurster; J S Lipsick; S M Hedrick
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

5.  Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

Authors:  K L Rock; L E Rothstein; S R Gamble; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

6.  Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells.

Authors:  Mary Philip; Andrea Schietinger; Hans Schreiber
Journal:  Immunology       Date:  2010-03-16       Impact factor: 7.397

7.  Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

Authors:  M A Campbell; B M Sefton
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

8.  Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.

Authors:  T Nakayama; L E Samelson; Y Nakayama; T I Munitz; M Sheard; C H June; A Singer
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

9.  The endo/lysosomal protease cathepsin B is able to process conalbumin fragments for presentation to T cells.

Authors:  G Gradehandt; E Ruede
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397

10.  Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family.

Authors:  S Z Domanico; D C DeNagel; J N Dahlseid; J M Green; S K Pierce
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272
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