| Literature DB >> 3095425 |
L E Samelson, A M Weissman, F A Robey, I Berkower, R D Klausner.
Abstract
The T cell antigen receptor consists of two disulfide-linked 40,000 to 45,000 dalton glycoproteins (alpha and beta) that contain variable and constant regions analogous to those found in immunoglobulin molecules. The antigen receptor on murine T cells is noncovalently associated with four additional nonpolymorphic structures. We describe an antibody that binds one of these molecules, a 26,000 dalton glycoprotein homologous to the human T3 delta-chain. This antibody immunoprecipitates the entire antigen receptor complex from a T cell hybridoma and from normal murine thymocytes. It represents the first reagent that can immunoprecipitate the antigen receptor complex on all murine T cells.Entities:
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Year: 1986 PMID: 3095425
Source DB: PubMed Journal: J Immunol ISSN: 0022-1767 Impact factor: 5.422