Hila Zelicha1, Alon Kaplan1, Anat Yaskolka Meir1, Gal Tsaban1, Ehud Rinott1, Ilan Shelef2, Amir Tirosh3,4, Dov Brikner5, Efrat Pupkin5, Lu Qi6, Joachim Thiery7, Michael Stumvoll7, Nora Kloting7, Martin von Bergen7, Uta Ceglarek7, Matthias Blüher7, Meir J Stampfer8, Iris Shai9. 1. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. 2. Soroka University Medical Center, Beer Sheva, Israel. 3. Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Tel Hashomer, Israel; and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 4. Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 5. Department of Medicine, Nuclear Research Center Negev, Dimona, Israel. 6. Department of Epidemiology, Tulane University, New Orleans, LA. 7. Department of Medicine, University of Leipzig, Leipzig, Germany. 8. Harvard T.H. Chan School of Public Health and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA. 9. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel irish@bgu.ac.il.
Abstract
OBJECTIVE: To compare the postprandial and overnight glycemic response using a novel green aquatic plant thought to provide a dietary source for high-quality protein, with an iso-carbohydrate/protein/caloric dairy shake. RESEARCH DESIGN AND METHODS: This is a randomized controlled crossover trial among 20 abdominally obese participants (age 51.4 years; fasting plasma glucose 110.9 mg/dL), who were allocated to replace dinner with either, first, a green shake containing Wolffia globosa duckweed (Mankai: specific-strain) or an iso-carbohydrate/protein/calorie yogurt shake. A 2-week flash glucose-monitoring system was used to assess postmeal glucose dynamics (6 net administration days; 97 observation days in total). We further obtained from each participant dietary/daily activity/satiety scale/sleep logs. Participants were recruited from the green-Mediterranean diet arm of the 18-month Dietary Intervention Randomized Controlled Trial-Polyphenols Unprocessed (DIRECT-PLUS) study. RESULTS: Wolffia globosa Mankai elicited a lower postprandial glucose peak compared with yogurt (∆peak = 13.4 ± 9.2 vs. 19.3 ± 15.1 mg/dL; P = 0.044), which occurred later (77.5 ± 29.2 vs. 59.2 ± 28.4 min; P = 0.037) and returned faster to baseline glucose levels (135.8 ± 53.1 vs. 197.5 ± 70.2 min; P = 0.012). The mean post-net incremental area under the curve (netAUC) was lower with Wolffia globosa up to 60 and 180 min (netAUC 60 min: 185.1 ± 340.1 vs. 441.4 ± 336.5 mg/dL/min, P = 0.005; netAUC 180 min: 707.9 ± 1,428.5 vs. 1,576.6 ± 1,810.1 mg/dL/min, P = 0.037). A Wolffia globosa-based shake replacing dinner resulted in lower next-morning fasting glucose levels (83.2 ± 0.8 vs. 86.6 ± 13 mg/dL; P = 0.041). Overall, postprandial glucose levels from the shake administration until the next morning were lower in the Wolffia globosa Mankai green shake compared with the yogurt shake (P < 0.001). Overnight sleep duration was similar (378.2 ± 22.4 vs. 375.9 ± 28.4 min; P = 0.72), and satiety rank was slightly higher for the Wolffia globosa shake compared with the yogurt shake (7.5 vs. 6.5; P = 0.035). CONCLUSIONS: Wolffia globosa Mankai duckweed may serve as an emerging alternative plant protein source with potential beneficial postprandial glycemic effects.
RCT Entities:
OBJECTIVE: To compare the postprandial and overnight glycemic response using a novel green aquatic plant thought to provide a dietary source for high-quality protein, with an iso-carbohydrate/protein/caloric dairy shake. RESEARCH DESIGN AND METHODS: This is a randomized controlled crossover trial among 20 abdominally obeseparticipants (age 51.4 years; fasting plasma glucose 110.9 mg/dL), who were allocated to replace dinner with either, first, a green shake containing Wolffia globosa duckweed (Mankai: specific-strain) or an iso-carbohydrate/protein/calorie yogurt shake. A 2-week flash glucose-monitoring system was used to assess postmeal glucose dynamics (6 net administration days; 97 observation days in total). We further obtained from each participant dietary/daily activity/satiety scale/sleep logs. Participants were recruited from the green-Mediterranean diet arm of the 18-month Dietary Intervention Randomized Controlled Trial-Polyphenols Unprocessed (DIRECT-PLUS) study. RESULTS:Wolffia globosa Mankai elicited a lower postprandial glucose peak compared with yogurt (∆peak = 13.4 ± 9.2 vs. 19.3 ± 15.1 mg/dL; P = 0.044), which occurred later (77.5 ± 29.2 vs. 59.2 ± 28.4 min; P = 0.037) and returned faster to baseline glucose levels (135.8 ± 53.1 vs. 197.5 ± 70.2 min; P = 0.012). The mean post-net incremental area under the curve (netAUC) was lower with Wolffia globosa up to 60 and 180 min (netAUC 60 min: 185.1 ± 340.1 vs. 441.4 ± 336.5 mg/dL/min, P = 0.005; netAUC 180 min: 707.9 ± 1,428.5 vs. 1,576.6 ± 1,810.1 mg/dL/min, P = 0.037). A Wolffia globosa-based shake replacing dinner resulted in lower next-morning fasting glucose levels (83.2 ± 0.8 vs. 86.6 ± 13 mg/dL; P = 0.041). Overall, postprandial glucose levels from the shake administration until the next morning were lower in the Wolffia globosa Mankai green shake compared with the yogurt shake (P < 0.001). Overnight sleep duration was similar (378.2 ± 22.4 vs. 375.9 ± 28.4 min; P = 0.72), and satiety rank was slightly higher for the Wolffia globosa shake compared with the yogurt shake (7.5 vs. 6.5; P = 0.035). CONCLUSIONS:Wolffia globosa Mankai duckweed may serve as an emerging alternative plant protein source with potential beneficial postprandial glycemic effects.
Authors: Jurriaan J Mes; Diederik Esser; Dianne Somhorst; Els Oosterink; Sandra van der Haar; Meeke Ummels; Els Siebelink; Ingrid M van der Meer Journal: Plant Foods Hum Nutr Date: 2022-02-12 Impact factor: 3.921
Authors: Alon Kaplan; Hila Zelicha; Anat Yaskolka Meir; Ehud Rinott; Gal Tsaban; Gidon Levakov; Ofer Prager; Moti Salti; Yoram Yovell; Jonathan Ofer; Sebastian Huhn; Frauke Beyer; Veronica Witte; Arno Villringer; Nachshon Meiran; Tamar B Emesh; Peter Kovacs; Martin von Bergen; Uta Ceglarek; Matthias Blüher; Michael Stumvoll; Frank B Hu; Meir J Stampfer; Alon Friedman; Ilan Shelef; Galia Avidan; Iris Shai Journal: Am J Clin Nutr Date: 2022-05-01 Impact factor: 8.472
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