Cornel iridoid glycoside exerts a neuroprotective effect on neuroinflammation in rats with brain injury by inhibiting NF-κB and STAT3.

Traumatic brain injury leads to problems with movement and cognitive deficits and has a high mortality rate. Cornel iridoid glycoside, the active ingredient of Cornus officinalis, has been reported to ameliorate apoptosis and inflammation in rats. We investigated the therapeutic effect of cornel iridoid glycoside on neuroinflammation in rats with brain injury. Rats were treated with cornel iridoid glycoside, and then measurements of antioxidant, proinflammatory marker, and NF-κB and STAT3 mRNA and protein levels, as well as a histopathologic analysis, were conducted. Cornel iridoid glycoside significantly reduced lipid peroxidation and TNF-α and IL-6 levels but increased the levels of antioxidants. In addition, cornel iridoid glycoside significantly decreased the expression of NF-κB and STAT3. Histopathological analyses showed that cornel iridoid glycoside reduced the severity of neuroinflammation and apoptosis. Therefore, cornel iridoid glycoside significantly ameliorated neuroinflammation by reducing lipid peroxidation and proinflammatory marker levels and increasing antioxidant levels in rats with brain injury.