| Literature DB >> 31033298 |
Munhyung Bae1, Joon Soo An1, Eun Seo Bae1, Jedo Oh1, So Hyun Park1, Yeonjung Lim2, Yeon Hee Ban3, Yun Kwon1, Jang-Cheon Cho2, Yeo Joon Yoon3, Sang Kook Lee1, Jongheon Shin1, Dong-Chan Oh1.
Abstract
The chemical analysis of a Streptomyces strain, from a Korean volcanic island, discovered new benz[ a]anthracene dimers linked by a thioether bond. The structures of donghaesulfins A and B (1 and 2) were elucidated by spectroscopic analysis including energy-dispersive X-ray. Their configurations were determined by ROESY NMR data, DP4 calculations, the modified Mosher's method, and ECD calculations. Donghaesulfins A (1) induced quinone reductase, whereas donghaesulfin B (2) displayed antiangiogenesis activity.Entities:
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Year: 2019 PMID： 31033298 DOI： 10.1021/acs.orglett.9b01057
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005