Literature DB >> 6417542

Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement.

P D Burrows, G B Beck-Engeser, M R Wabl.   

Abstract

Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin mu to gamma 2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and C gamma 2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both mu- and gamma 2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.

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Year:  1983        PMID： 6417542     DOI： 10.1038/306243a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  35 in total

1.  Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells.

Authors:  R A Wuerffel; A T Nathan; A L Kenter
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

2.  Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.

Authors:  G Beck-Engeser; H M Jäck; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

3.  High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene.

Authors:  J Meyer; H M Jäck; N Ellis; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

4.  Biochemical and physiochemical characteristics of a pre-B cell stimulating factor produced by the plasmacytoma cell line LICR LON HMY2.

Authors:  A Trudgett; A C Fay; J M Thompson; T A McNeill
Journal:  Clin Exp Immunol       Date:  1985-03       Impact factor: 4.330

5.  Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses.

Authors:  C F Webb; M D Cooper; P D Burrows; J A Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

6.  Presence of immunoglobulin (Ig) M and IgG double isotype-bearing cells and defect of switch recombination in hyper IgM immunodeficiency.

Authors:  Y Akahori; Y Kurosawa; Y Kamachi; S Torii; H Matsuoka
Journal:  J Clin Invest       Date:  1990-06       Impact factor: 14.808

7.  A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation.

Authors:  S H Waters; K U Saikh; J Stavnezer
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

8.  Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.

Authors:  Albert G Tsai; Haihui Lu; Sathees C Raghavan; Markus Muschen; Chih-Lin Hsieh; Michael R Lieber
Journal:  Cell       Date:  2008-12-12       Impact factor: 41.582

9.  Early pre-B-cell transformation induced by the v-fms oncogene in long-term mouse bone marrow cultures.

Authors:  G V Borzillo; C J Sherr
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

10.  Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

Authors:  E Sakai; A Bottaro; L Davidson; B P Sleckman; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205
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