Takuya Mitsumoto1,2, Ryogo Minamimoto2, Fumio Sunaoka2, Seishi Kishimoto1, Kazumasa Inoue3, Masahiro Fukushi3. 1. 1 Department of Radioisotope Research Center, Teikyo university , Tokyo. 2. 2 Department of Radiology, National Center for Global Health and Medicine , Tokyo. 3. 3 Department of Radiological Sciences, Graduate School of Medicine, Tokyo Metropolitan University , Tokyo.
Abstract
OBJECTIVE: We developed a new respiratory-gated positron emission tomography (PET) imaging method (RGV-PET) that phase-based respiratory gated PET imaging (RG-PET) combine with head-mounted display (HMD)-guided "visual feedback." The purpose of this study was to investigate whether RGV-PET is effective at improving the quantitative measurement of tracer uptake in tumors using the phase-based respiratory gating method. METHODS: Of the 41 enrolled patients with hepatobiliary or pancreatic cancer, 20 patients underwent RGV-PET and the remaining 21 patients underwent RG-PET. We measured the peak standardized uptake value (SUVpeak) of the primary lesion in each five bins obtained from both RG-PET and RGV-PET. The SUVpeak change rate calculated based on the ungated PET imaging. To evaluate the quantitative variation, the coefficient of variation of the SUVpeak change rate was compared between RG-PET and RGV-PET. In addition, we performed qualitative evaluation using visual score for the incidence of artifacts on four-dimensional-CT. RESULTS: The coefficient of variation of the average SUVpeak change rate in RGV-PET was 7.01 ± 4.43, which was significantly lower than the values in RG-PET (10.72 ± 5.74, p < 0.05). A significant improvement in the SUVpeak change rate of RGV-PET was obtained in bins 1 and 2 compared to RG-PET ( p < 0.05). The visual score of RGV-PET was significantly lower than RG-PET ( p < 0.05). CONCLUSION: RGV-PET was effective for respiratory stabilization and improved respiratory gating imaging quality. ADVANCES IN KNOWLEDGE: The RGV-PET is applicable to various PET/CT respiratory gating imaging and may improve the quantitativeness of PET images.
OBJECTIVE: We developed a new respiratory-gated positron emission tomography (PET) imaging method (RGV-PET) that phase-based respiratory gated PET imaging (RG-PET) combine with head-mounted display (HMD)-guided "visual feedback." The purpose of this study was to investigate whether RGV-PET is effective at improving the quantitative measurement of tracer uptake in tumors using the phase-based respiratory gating method. METHODS: Of the 41 enrolled patients with hepatobiliary or pancreatic cancer, 20 patients underwent RGV-PET and the remaining 21 patients underwent RG-PET. We measured the peak standardized uptake value (SUVpeak) of the primary lesion in each five bins obtained from both RG-PET and RGV-PET. The SUVpeak change rate calculated based on the ungated PET imaging. To evaluate the quantitative variation, the coefficient of variation of the SUVpeak change rate was compared between RG-PET and RGV-PET. In addition, we performed qualitative evaluation using visual score for the incidence of artifacts on four-dimensional-CT. RESULTS: The coefficient of variation of the average SUVpeak change rate in RGV-PET was 7.01 ± 4.43, which was significantly lower than the values in RG-PET (10.72 ± 5.74, p < 0.05). A significant improvement in the SUVpeak change rate of RGV-PET was obtained in bins 1 and 2 compared to RG-PET ( p < 0.05). The visual score of RGV-PET was significantly lower than RG-PET ( p < 0.05). CONCLUSION: RGV-PET was effective for respiratory stabilization and improved respiratory gating imaging quality. ADVANCES IN KNOWLEDGE: The RGV-PET is applicable to various PET/CT respiratory gating imaging and may improve the quantitativeness of PET images.
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Authors: S A Nehmeh; Y E Erdi; T Pan; A Pevsner; K E Rosenzweig; E Yorke; G S Mageras; H Schoder; Phil Vernon; O Squire; H Mostafavi; S M Larson; J L Humm Journal: Med Phys Date: 2004-12 Impact factor: 4.071
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Authors: Gustavo S P Meirelles; Yusuf Emre Erdi; Sadek A Nehmeh; Olivia D Squire; Steven M Larson; John L Humm; Heiko Schöder Journal: J Nucl Med Date: 2007-05 Impact factor: 10.057