Literature DB >> 31002925

Frailty biomarkers in humans and rodents: Current approaches and future advances.

Alice E Kane1, David A Sinclair2.   

Abstract

Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aging; Animal models; Biological age; Deficit accumulation; Epigenetics; Sex differences

Mesh：

Substances：

Year:  2019        PMID： 31002925      PMCID： PMC6581034          DOI： 10.1016/j.mad.2019.03.007

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  123 in total

Review 1.  Biomarkers of frailty in older persons.

Authors:  L Ferrucci; C Cavazzini; A Corsi; B Bartali; C R Russo; F Lauretani; L Ferrucci; C Cavazzini; A M Corsi; B Bartali; C R Russo; F Lauretani; S Bandinelli; S Bandinelli; J M Guralnik
Journal:  J Endocrinol Invest       Date:  2002       Impact factor: 4.256

Review 2.  C-reactive protein: a critical update.

Authors:  Mark B Pepys; Gideon M Hirschfield
Journal:  J Clin Invest       Date:  2003-06       Impact factor: 14.808

3.  A new approach to the concept and computation of biological age.

Authors:  Petr Klemera; Stanislav Doubal
Journal:  Mech Ageing Dev       Date:  2005-11-28       Impact factor: 5.432

4.  Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study.

Authors:  Jeremy Walston; Mary Ann McBurnie; Anne Newman; Russell P Tracy; Willem J Kop; Calvin H Hirsch; John Gottdiener; Linda P Fried
Journal:  Arch Intern Med       Date:  2002-11-11

5.  Endocrine and inflammatory markers as predictors of frailty.

Authors:  Martine T E Puts; Marjolein Visser; Jos W R Twisk; Dorly J H Deeg; Paul Lips
Journal:  Clin Endocrinol (Oxf)       Date:  2005-10       Impact factor: 3.478

6.  Sex differences in the risk of frailty for mortality independent of disability and chronic diseases.

Authors:  Martine T E Puts; Paul Lips; Dorly J H Deeg
Journal:  J Am Geriatr Soc       Date:  2005-01       Impact factor: 5.562

7.  T cell subsets and mortality in older community-dwelling women.

Authors:  Richard D Semba; Joseph B Margolick; Sean Leng; Jeremy Walston; Michelle O Ricks; Linda P Fried
Journal:  Exp Gerontol       Date:  2005 Jan-Feb       Impact factor: 4.032

8.  Frailty in older adults: evidence for a phenotype.

Authors:  L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2001-03       Impact factor: 6.053

9.  Decreased cell proliferation and altered cytokine production in frail older adults.

Authors:  Sean X Leng; Huanle Yang; Jeremy D Walston
Journal:  Aging Clin Exp Res       Date:  2004-06       Impact factor: 3.636

10.  Accumulation of deficits as a proxy measure of aging.

Authors:  A B Mitnitski; A J Mogilner; K Rockwood
Journal:  ScientificWorldJournal       Date:  2001-08-08
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  18 in total

1.  Frailty as a Prognostic Indicator in Intensive Care.

Authors:  Christian Jung; Raphael Romano Bruno; Bernhard Wernly; Georg Wolff; Michael Beil; Malte Kelm
Journal:  Dtsch Arztebl Int       Date:  2020-10-02       Impact factor: 5.594

2.  A Metabolite Composite Score Attenuated a Substantial Portion of the Higher Mortality Risk Associated With Frailty Among Community-Dwelling Older Adults.

Authors:  Megan M Marron; Tamara B Harris; Robert M Boudreau; Clary B Clish; Steven C Moore; Rachel A Murphy; Venkatesh L Murthy; Jason L Sanders; Ravi V Shah; George C Tseng; Stacy G Wendell; Joseph M Zmuda; Anne B Newman
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2021-01-18       Impact factor: 6.053

Review 3.  Frailty, aging, and periodontal disease: Basic biologic considerations.

Authors:  Daniel Clark; Eftychia Kotronia; Sheena E Ramsay
Journal:  Periodontol 2000       Date:  2021-10       Impact factor: 7.589

4.  Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging.

Authors:  Chris P Verschoor; David T S Lin; Michael S Kobor; Oxana Mian; Jinhui Ma; Guillaume Pare; Gustavo Ybazeta
Journal:  Clin Epigenetics       Date:  2021-08-23       Impact factor: 6.551

5.  Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy.

Authors:  Cristina Buigues; Rut Navarro-Martínez; Vanessa Sánchez-Martínez; María Serrano-Carrascosa; José Rubio-Briones; Omar Cauli
Journal:  Cancers (Basel)       Date:  2020-06-29       Impact factor: 6.639

6.  Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

Authors:  Daniel S Evans; Monique N O'Leary; Ryan Murphy; Minna Schmidt; Kristin Koenig; Michael Presley; Brittany Garrett; Ha-Neui Kim; Li Han; Emmeline C Academia; Matt J Laye; Daniel Edgar; Christopher A Zambataro; Tracey Barhydt; Colleen M Dewey; Jarrott Mayfield; Joy Wilson; Silvestre Alavez; Mark Lucanic; Brian K Kennedy; Maria Almeida; Julie K Andersen; Pankaj Kapahi; Gordon J Lithgow; Simon Melov
Journal:  JBMR Plus       Date:  2021-02-16

7.  IL-6 can singlehandedly drive many features of frailty in mice.

Authors:  Mladen Jergović; Heather L Thompson; Christine M Bradshaw; Sandip Ashok Sonar; Arveen Ashgar; Niels Mohty; Bellal Joseph; Mindy J Fain; Kristan Cleveland; Rick G Schnellman; Janko Nikolich-Žugich
Journal:  Geroscience       Date:  2021-02-24       Impact factor: 7.713

Review 8.  Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models.

Authors:  María Álvarez-Satta; Alejandro Berna-Erro; Estefania Carrasco-Garcia; Ainhoa Alberro; Ander Saenz-Antoñanzas; Itziar Vergara; David Otaegui; Ander Matheu
Journal:  Aging (Albany NY)       Date:  2020-05-27       Impact factor: 5.682

9.  Functional Age Predicted by Electronic Short Physical Performance Battery Can Detect Frailty Status in Older Adults.

Authors:  Hee-Won Jung; Taeyang Jin; Ji Yeon Baek; Seongjun Yoon; Eunju Lee; Jack M Guralnik; Il-Young Jang
Journal:  Clin Interv Aging       Date:  2020-11-11       Impact factor: 4.458

10.  Maladaptive Changes Associated With Cardiac Aging Are Sex-Specific and Graded by Frailty and Inflammation in C57BL/6 Mice.

Authors:  Alice E Kane; Elise S Bisset; Stefan Heinze-Milne; Kaitlyn M Keller; Scott A Grandy; Susan E Howlett
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2021-01-18       Impact factor: 6.053
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